The rapid emergence of antifungal-resistant human-pathogenic fungi

SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …

Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment

MC Arendrup, TF Patterson - The Journal of infectious diseases, 2017 - academic.oup.com
Invasive Candida infections remain an important cause of morbidity and mortality, especially
in hospitalized and immunocompromised or critically ill patients. A limited number of …

[HTML][HTML] Emerging threats in antifungal-resistant fungal pathogens

D Sanglard - Frontiers in medicine, 2016 - frontiersin.org
The use of antifungal drugs in the therapy of fungal diseases can lead to the development of
antifungal resistance. Resistance has been described for virtually all antifungal agents in …

[HTML][HTML] Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens

E Ksiezopolska, T Gabaldón - Genes, 2018 - mdpi.com
Fungal infections, such as candidiasis caused by Candida, pose a problem of growing
medical concern. In developed countries, the incidence of Candida infections is increasing …

[HTML][HTML] On the Origins of a Species: What Might Explain the Rise of Candida auris?

BR Jackson, N Chow, K Forsberg, AP Litvintseva… - Journal of Fungi, 2019 - mdpi.com
Candida auris is an emerging multidrug-resistant yeast first described in 2009 that has since
caused healthcare-associated outbreaks of severe human infections around the world. In …

New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics

J Geddes‐McAlister, RS Shapiro - … of the New York Academy of …, 2019 - Wiley Online Library
Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …

A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise

KC Howard, EK Dennis, DS Watt… - Chemical Society …, 2020 - pubs.rsc.org
The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease

M Hoenigl, A Arastehfar, MC Arendrup… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Fungal infections are on the rise, driven by a growing population at risk and climate change.
Currently available antifungals include only five classes, and their utility and efficacy in …

Rapid evolution of multidrug resistance in a Candida lusitaniae infection during micafungin monotherapy

NE Scott, S Edwin Erayil, SE Kline… - Antimicrobial agents …, 2023 - Am Soc Microbiol
Candida (Clavispora) lusitaniae is a rare, emerging non-albicans Candida species that can
cause life-threatening invasive infections, spread within hospital settings, and rapidly …

Use of RNA-Protein Complexes for Genome Editing in Non-albicans Candida Species

N Grahl, EG Demers, AW Crocker, DA Hogan - Msphere, 2017 - Am Soc Microbiol
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 genome
modification systems have greatly facilitated the genetic analysis of fungal pathogens. In …