The rapid emergence of antifungal-resistant human-pathogenic fungi
SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …
health threat, particularly given the limited number of antifungal drugs available to treat …
Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment
MC Arendrup, TF Patterson - The Journal of infectious diseases, 2017 - academic.oup.com
Invasive Candida infections remain an important cause of morbidity and mortality, especially
in hospitalized and immunocompromised or critically ill patients. A limited number of …
in hospitalized and immunocompromised or critically ill patients. A limited number of …
[HTML][HTML] Emerging threats in antifungal-resistant fungal pathogens
D Sanglard - Frontiers in medicine, 2016 - frontiersin.org
The use of antifungal drugs in the therapy of fungal diseases can lead to the development of
antifungal resistance. Resistance has been described for virtually all antifungal agents in …
antifungal resistance. Resistance has been described for virtually all antifungal agents in …
[HTML][HTML] Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens
E Ksiezopolska, T Gabaldón - Genes, 2018 - mdpi.com
Fungal infections, such as candidiasis caused by Candida, pose a problem of growing
medical concern. In developed countries, the incidence of Candida infections is increasing …
medical concern. In developed countries, the incidence of Candida infections is increasing …
[HTML][HTML] On the Origins of a Species: What Might Explain the Rise of Candida auris?
BR Jackson, N Chow, K Forsberg, AP Litvintseva… - Journal of Fungi, 2019 - mdpi.com
Candida auris is an emerging multidrug-resistant yeast first described in 2009 that has since
caused healthcare-associated outbreaks of severe human infections around the world. In …
caused healthcare-associated outbreaks of severe human infections around the world. In …
New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics
J Geddes‐McAlister, RS Shapiro - … of the New York Academy of …, 2019 - Wiley Online Library
Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …
becomes increasingly common, fungal infections are becoming more prevalent. The use of …
A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise
The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …
medical imperative that in recent years motivates the talents of numerous investigators …
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Fungal infections are on the rise, driven by a growing population at risk and climate change.
Currently available antifungals include only five classes, and their utility and efficacy in …
Currently available antifungals include only five classes, and their utility and efficacy in …
Rapid evolution of multidrug resistance in a Candida lusitaniae infection during micafungin monotherapy
NE Scott, S Edwin Erayil, SE Kline… - Antimicrobial agents …, 2023 - Am Soc Microbiol
Candida (Clavispora) lusitaniae is a rare, emerging non-albicans Candida species that can
cause life-threatening invasive infections, spread within hospital settings, and rapidly …
cause life-threatening invasive infections, spread within hospital settings, and rapidly …
Use of RNA-Protein Complexes for Genome Editing in Non-albicans Candida Species
N Grahl, EG Demers, AW Crocker, DA Hogan - Msphere, 2017 - Am Soc Microbiol
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 genome
modification systems have greatly facilitated the genetic analysis of fungal pathogens. In …
modification systems have greatly facilitated the genetic analysis of fungal pathogens. In …