[HTML][HTML] Superoxide anion chemistry—Its role at the core of the innate immunity
CMC Andrés, JM Pérez de la Lastra… - International journal of …, 2023 - mdpi.com
Classically, superoxide anion O2•− and reactive oxygen species ROS play a dual role. At
the physiological balance level, they are a by-product of O2 reduction, necessary for cell …
the physiological balance level, they are a by-product of O2 reduction, necessary for cell …
[HTML][HTML] Challenges and advances in clinical applications of mesenchymal stromal cells
T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …
intensely investigated for clinical applications within the last decades. However, the majority …
Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
[HTML][HTML] Modulation of the inflammatory response and bone healing
M Maruyama, C Rhee, T Utsunomiya… - Frontiers in …, 2020 - frontiersin.org
The optimal treatment for complex fractures and large bone defects is an important unsolved
issue in orthopedics and related specialties. Approximately 5–10% of fractures fail to heal …
issue in orthopedics and related specialties. Approximately 5–10% of fractures fail to heal …
[HTML][HTML] Mesenchymal stem cells and their microenvironment
J Liu, J Gao, Z Liang, C Gao, Q Niu, F Wu… - Stem Cell Research & …, 2022 - Springer
Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-
directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis …
directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis …
[HTML][HTML] Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications
Y Huang, Q Wu, PKH Tam - International Journal of Molecular Sciences, 2022 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity of self-renewal,
homing, and low immunogenicity. These distinct biological characteristics have already …
homing, and low immunogenicity. These distinct biological characteristics have already …
[HTML][HTML] Current knowledge and future perspectives on mesenchymal stem cell-derived exosomes as a new therapeutic agent
Mesenchymal stem cells (MSCs) are on the cusp of regenerative medicine due to their
differentiation capacity, favorable culture conditions, ability to be manipulated in vitro, and …
differentiation capacity, favorable culture conditions, ability to be manipulated in vitro, and …
Effects of mesenchymal stem cell‐derived paracrine signals and their delivery strategies
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for
tissue regeneration and remodeling due to their potent bioactivity, which includes …
tissue regeneration and remodeling due to their potent bioactivity, which includes …
[HTML][HTML] Therapeutic properties of mesenchymal stromal/stem cells: the need of cell priming for cell-free therapies in regenerative medicine
Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem cells that support
homeostasis during tissue regeneration. In the last decade, cell therapies based on the use …
homeostasis during tissue regeneration. In the last decade, cell therapies based on the use …
Cell therapies in the clinic
Cell therapies have emerged as a promising therapeutic modality with the potential to treat
and even cure a diverse array of diseases. Cell therapies offer unique clinical and …
and even cure a diverse array of diseases. Cell therapies offer unique clinical and …