Engineered human blood–brain barrier microfluidic model for vascular permeability analyses
The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …
therapeutic molecules into the brain. Due to challenges in translating results from animal …
Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature
Human organoids, self-organized and differentiated from homogenous pluripotent stem cells
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …
Biology and models of the blood–brain barrier
The blood–brain barrier (BBB) is one of the most selective endothelial barriers. An
understanding of its cellular, morphological, and biological properties in health and disease …
understanding of its cellular, morphological, and biological properties in health and disease …
A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles
The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …
gliomas, and our understanding of drug transport across this critical biointerface remains …
[HTML][HTML] Omentum-on-a-chip: A multicellular, vascularized microfluidic model of the human peritoneum for the study of ovarian cancer metastases
Epithelial ovarian cancer has the highest mortality rate of any gynecologic malignancy and
most frequently metastasizes to the peritoneal cavity. Intraperitoneal metastases are highly …
most frequently metastasizes to the peritoneal cavity. Intraperitoneal metastases are highly …
Endothelial regulation of drug transport in a 3D vascularized tumor model
Drug discovery and efficacy in cancer treatments are limited by the inability of pre‐clinical
models to predict successful outcomes in humans. Limitations remain partly due to their lack …
models to predict successful outcomes in humans. Limitations remain partly due to their lack …
[HTML][HTML] The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform
Throughout the process of metastatic dissemination, tumor cells are continuously subjected
to mechanical forces resulting from complex fluid flows due to changes in pressures in their …
to mechanical forces resulting from complex fluid flows due to changes in pressures in their …
Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians
G Simitian, M Virumbrales-Muñoz… - Lab on a Chip, 2022 - pubs.rsc.org
Neovascularization, the formation of new blood vessels, has received much research
attention due to its implications for physiological processes and diseases. Most studies …
attention due to its implications for physiological processes and diseases. Most studies …
The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination
The glycocalyx on tumor cells has been recently identified as an important driver for cancer
progression, possibly providing critical opportunities for treatment. Metastasis, in particular …
progression, possibly providing critical opportunities for treatment. Metastasis, in particular …
Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment
Macrophages are abundant in the tumor microenvironment (TME), serving as accomplices
to cancer cells for their invasion. Studies have explored the biochemical mechanisms that …
to cancer cells for their invasion. Studies have explored the biochemical mechanisms that …