Structural insights into how proteoglycans determine chemokine-CXCR1/CXCR2 interactions: progress and challenges
K Rajarathnam, UR Desai - Frontiers in immunology, 2020 - frontiersin.org
Proteoglycans (PGs), present in diverse environments, such as the cell membrane surface,
extracellular milieu, and intracellular granules, are fundamental to life. Sulfated …
extracellular milieu, and intracellular granules, are fundamental to life. Sulfated …
pH-dependent random coil 1H, 13C, and 15N chemical shifts of the ionizable amino acids: a guide for protein pK a measurements
G Platzer, M Okon, LP McIntosh - Journal of biomolecular NMR, 2014 - Springer
The p K a values and charge states of ionizable residues in polypeptides and proteins are
frequently determined via NMR-monitored pH titrations. To aid the interpretation of the …
frequently determined via NMR-monitored pH titrations. To aid the interpretation of the …
Physicochemical properties of ion pairs of biological macromolecules
Ion pairs (also known as salt bridges) of electrostatically interacting cationic and anionic
moieties are important for proteins and nucleic acids to perform their function. Although …
moieties are important for proteins and nucleic acids to perform their function. Although …
A novel approach for nanobubble generation toward biomedical applications
The stability of free-standing nanobubbles is a long-standing controversial problem due to
the Laplace pressure catastrophe at the nanoscale. In most industrial circumstances, a large …
the Laplace pressure catastrophe at the nanoscale. In most industrial circumstances, a large …
Biophysical chemistry behind sickle cell anemia and the mechanism of voxelotor action
M Suhail - Scientific Reports, 2024 - nature.com
Sickle cell anemia disease has been a great challenge to the world in the present situation.
It occurs only due to the polymerization of sickle hemoglobin (HbS) having Pro–Val–Glu …
It occurs only due to the polymerization of sickle hemoglobin (HbS) having Pro–Val–Glu …
Dynamics and recognition within a protein–DNA complex: a molecular dynamics study of the SKN-1/DNA interaction
Molecular dynamics simulations of the Caenorhabditis elegans transcription factor SKN-1
bound to its cognate DNA site show that the protein–DNA interface undergoes significant …
bound to its cognate DNA site show that the protein–DNA interface undergoes significant …
Changes in conformational dynamics of basic side chains upon protein–DNA association
Basic side chains play major roles in recognition of nucleic acids by proteins. However,
dynamic properties of these positively charged side chains are not well understood. In this …
dynamic properties of these positively charged side chains are not well understood. In this …
Protein–DNA interfaces: a molecular dynamics analysis of time-dependent recognition processes for three transcription factors
We have studied the dynamics of three transcription factor–DNA complexes using all-atom,
microsecond-scale MD simulations. In each case, the salt bridges and hydrogen bond …
microsecond-scale MD simulations. In each case, the salt bridges and hydrogen bond …
New tools to probe the protein surface: ultrasmall gold nanoparticles carry amino acid binders
SB van der Meer, I Hadrovic, A Meiners… - The Journal of …, 2020 - ACS Publications
A strategy toward epitope-selective functionalized nanoparticles is introduced in the
following: ultrasmall gold nanoparticles (diameter of the metallic core about 2 nm) were …
following: ultrasmall gold nanoparticles (diameter of the metallic core about 2 nm) were …
Entropic enhancement of protein-DNA affinity by oxygen-to-sulfur substitution in DNA phosphate
Dithioation of DNA phosphate is known to enhance binding affinities, at least for some
proteins. We mechanistically characterized this phenomenon for the Antennapedia …
proteins. We mechanistically characterized this phenomenon for the Antennapedia …