Membrane transporters are integral membrane proteins that mediate the passage of solutes
across lipid bilayers. These proteins undergo conformational transitions between outward …

Thiamine plays a very important coenzymatic and non-coenzymatic role in the regulation of
basic metabolism. Thiamine diphosphate is a coenzyme of many enzymes, most of which …

Abstract Energy-coupling factor (ECF)-type transporters mediate the uptake of micronutrients
in many bacteria. They consist of a substrate-translocating subunit (S-component) and an …

The energy-coupling factor (ECF) transporters are a family of transmembrane proteins
involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of …

Energy-coupling factor (ECF)–type ATP-binding cassette (ABC) transporters catalyze
membrane transport of micronutrients in prokaryotes. Crystal structures and biochemical …

Energy-coupling factor (ECF) transporters mediate uptake of micronutrients in prokaryotes.
The transporters consist of an S-component that binds the transported substrate and an ECF …

The processes of nutrient uptake and signal sensing are crucial for microbial survival and
adaptation. Membrane-embedded proteins involved in these functions (transporters and …

Inhibition of thiamine pyrophosphate (TPP)-dependent enzymes with thiamine/TPP
analogues that have the central thiazolium ring replaced with other rings is well established …

Suppression of pyruvate dehydrogenase complex (PDHc) is a mechanism for cancer cells to
manifest the Warburg effect. However, recent evidence suggests that whether PDHc activity …

Thiamine diphosphate (ThDP), the bioactive form of vitamin B 1, is an essential coenzyme
needed for processes of cellular metabolism in all organisms. ThDP-dependent enzymes all …