Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia
associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in …

Diabetes has reached epidemic proportions worldwide. Currently, approximately 537 million
adults (20–79 years) have diabetes, and the total number of people with diabetes is …

In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD+)
biosynthesis, which contributes to metabolic dysfunction. Nicotinamide mononucleotide …

BACKGROUND: In patients with type 2 diabetes, intensive blood-glucose control with insulin
or sulphonylurea therapy decreases progression of microvascular disease and may also …

Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes.
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …

Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis.
Recent studies in animal models have indicated that TNF-alpha plays an important role in …

▪ Abstract The peroxisome proliferator-activated receptors (PPARs) are a group of three
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …

Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue
and directly sensitizes the body to insulin. Hypoadiponectinemia, caused by interactions of …

Absorption of monosaccharides is mainly mediated by Na+-d-glucose cotransporter SGLT1
and the facititative transporters GLUT2 and GLUT5. SGLT1 and GLUT2 are relevant for …

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …