Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

The calcium-based intracellular signalling system is used ubiquitously to couple
extracellular stimuli to their characteristic intracellular responses. It is becoming clear from …

The ER membrane-spanning STIM1 protein is a finely-tuned sensor of ER luminal Ca 2+.
Small changes in ER Ca 2+ induce STIM1 to undergo an intricate self-triggering process …

Orai channels mediate store-operated Ca 2+ signals crucial in regulating transcription in
many cell types, and implicated in numerous immunological and inflammatory disorders …

Store-operated Ca 2+ entry, essential for the adaptive immunity, is initiated by the
endoplasmic reticulum (ER) Ca 2+ sensor STIM1. Ca 2+ entry occurs through the plasma …

Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels
triggers diverse signaling cascades that affect cellular processes like cell growth, gene …

Background: STIM1 and Orai1, reconstituting a main cellular Ca 2+ entry pathway, interact
via their cytosolic strands. Results: The extended transmembrane Orai1 N-terminal (ETON) …

Abstract The ubiquitously expressed Orai Ca2+ channels are gated through a unique
process of intermembrane coupling with the Ca2+-sensing STIM proteins. Despite the …

The changes in intracellular free calcium (Ca2+) levels are one of the most widely regulators
of cell function; therefore, calcium as a universal intracellular mediator is involved in very …

Targeting epigenetic pathways is a promising approach for cancer therapy. Here, we report
on the unexpected finding that targeting calcium signaling can reverse epigenetic silencing …