Autoimmune hepatitis is a rare chronic inflammatory liver disease, affecting all ages,
characterised by elevated transaminase and immunoglobulin G levels, positive …

Objective We aimed to provide an evidence-supported update of the ECCO-ESPGHAN
guideline on the medical management of paediatric Crohn's disease [CD]. Methods We …

Personalized medicine, with the aim of safely, effectively, and cost-effectively targeting
treatment to a prespecified patient population, has always been a long-time goal within …

Background Pretherapy assessment of specific genetic polymorphism (TPMT, NUDT15,
FTO, RUNX1, etc) or enzyme levels (for TPMT) may help personalize the dose of thiopurines …

Aim Adverse drug events lead to increased morbidity, mortality and health care costs.
Pharmacogenetic testing that guides drug prescribing has the potential to reduced adverse …

Abstract Background and Aims Decreased thiopurine S-methyltransferase [TPMT] enzyme
activity increases the risk of haematological adverse drug reactions [ADRs] in patients …

Background Genetic testing has potential roles in identifying whether an individual would
have risk of adverse drug reactions (ADRs) from a particular medicine. Robust cost …

Background Nucleotide triphosphate diphosphatase (NUDT15) genetic testing in addition to
thiopurine methyl transferase (TPMT) is recommended to reduce the incidence of adverse …

Pharmacogenomics, driven by advances in genomics, helps to explain patients' individual
variability in response to therapies. Personalized medicine, the application of the increasing …

Pharmacogenomics is the study of the effects of genetic polymorphisms on medication
pharmacokinetics and pharmacodynamics. It offers advantages in predicting drug efficacy …