Molecular mechanisms of the toll-like receptor, STING, MAVS, inflammasome, and interferon pathways
NP Manes, A Nita-Lazar - Msystems, 2021 - Am Soc Microbiol
Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many
of the molecular mechanisms that facilitate PRR signaling have been characterized in detail …
of the molecular mechanisms that facilitate PRR signaling have been characterized in detail …
Elevated pre-activation basal level of nuclear NF-κB in native macrophages accelerates LPS-induced translocation of cytosolic NF-κB into the cell nucleus
AV Bagaev, AY Garaeva, ES Lebedeva, AV Pichugin… - Scientific reports, 2019 - nature.com
Signaling via Toll-like receptor 4 (TLR4) in macrophages constitutes an essential part of the
innate immune response to bacterial infections. Detailed and quantified descriptions of …
innate immune response to bacterial infections. Detailed and quantified descriptions of …
LPS-mediated activation of TLR4 controls Toxoplasma gondii growth in human trophoblast cell (BeWo) and human villous explants in a dependent-manner of TRIF …
AM Rosini, SC Teixeira, ICB Milian, RJ Silva… - Tissue and Cell, 2022 - Elsevier
We evaluated the influence of the Toll-like receptor (TLR)-4 pathways on BeWo, JEG-3 and
HTR-8/SVneo cells, as well as in human villous explants infected with Toxoplasma gondii …
HTR-8/SVneo cells, as well as in human villous explants infected with Toxoplasma gondii …
Linoleic acid causes greater weight gain than saturated fat without hypothalamic inflammation in the male mouse
KJ Mamounis, A Yasrebi, TA Roepke - The Journal of nutritional …, 2017 - Elsevier
A significant change in the Western diet, concurrent with the obesity epidemic, was a
substitution of saturated fatty acids with polyunsaturated, specifically linoleic acid (LA) …
substitution of saturated fatty acids with polyunsaturated, specifically linoleic acid (LA) …
Efficacy of Sishen Wan (四神丸) on dinitrobenzene sulfonic acidinduced ulcerative colitis and its effect on toll-like receptor 2/interleukin-1 receptor-associated kinase-4 …
Z Zhaohua, LIU Rong, DU Nana… - Journal of Traditional …, 2022 - search.ebscohost.com
OBJECTIVE: To investigate the therapeutic effect of Sishen Wan (四神丸, SSW) on ulcerative
colitis (UC) induced by dinitrobenzene sulfonic acid and its effect on toll-like receptor …
colitis (UC) induced by dinitrobenzene sulfonic acid and its effect on toll-like receptor …
Toll-Like Receptor 3–TRIF Pathway Activation by Neospora caninum RNA Enhances Infection Control in Mice
VS Miranda, FBF França, MS da Costa… - Infection and …, 2019 - Am Soc Microbiol
Neospora caninum is a protozoan parasite closely related to Toxoplasma gondii and has
been studied for causing neuromuscular disease in dogs and abortions in cattle. It is …
been studied for causing neuromuscular disease in dogs and abortions in cattle. It is …
Protein tyrosine kinase Fyn regulates TLR4-elicited responses on mast cells controlling the function of a PP2A-PKCα/β signaling node leading to TNF secretion
A Martín-Ávila, J Medina-Tamayo… - The Journal of …, 2016 - journals.aai.org
Mast cells produce proinflammatory cytokines in response to TLR4 ligands, but the signaling
pathways involved are not fully described. In this study, the participation of the Src family …
pathways involved are not fully described. In this study, the participation of the Src family …
Dysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia
N Li, Y Li, J Huang, P Zhang, J Tong, S Chen, Y Cui… - Neuroscience …, 2022 - Elsevier
Background Mounting evidence suggests that the innate immune system is disrupted in
schizophrenia patients with tardive dyskinesia (TD); however, the role of the toll-like receptor …
schizophrenia patients with tardive dyskinesia (TD); however, the role of the toll-like receptor …
Gain-of-function mutations in the toll-like receptor pathway: TPL2-mediated ERK1/ERK2 MAPK activation, a path to tumorigenesis in lymphoid neoplasms?
S Rousseau, G Martel - Frontiers in cell and developmental biology, 2016 - frontiersin.org
Lymphoid neoplasms form a family of cancers affecting B-cells, T-cells, and NK cells. The
Toll-Like Receptor (TLR) signaling adapter molecule MYD88 is the most frequently mutated …
Toll-Like Receptor (TLR) signaling adapter molecule MYD88 is the most frequently mutated …
MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239
Q Shi, B Xiong, J Zhong, H Wang, D Ma, C Miao - Molecular Immunology, 2017 - Elsevier
TLR4, an important Toll-like receptor in innate immunity, can be activated by LPS and
induce proinflammatory cytokines to resist invasion of pathogenic microorganism, but …
induce proinflammatory cytokines to resist invasion of pathogenic microorganism, but …