Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …

Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …

Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …

Neurons are metabolically active cells with high energy demands at locations distant from
the cell body. As a result, these cells are particularly dependent on mitochondrial function …

Mitochondrial dynamics and mitophagy are recognized as two critical processes underlying
mitochondrial homeostasis. Morphological and bioenergetic characterization of the life cycle …

Mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD) neurons. In this
study, we explored the involvement of an abnormal mitochondrial dynamics by investigating …

It has been only 15 years since studies began on the molecular mechanisms underlying
mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast …

Continuous turnover of intracellular components by autophagy is necessary to preserve
cellular homeostasis in all tissues. Alterations in macroautophagy, the main process …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …

In recent years, several important advances have been made in our understanding of the
pathways that lead to cell dysfunction and death in Parkinson's disease (PD) and …