Inherited retinal dystrophies and optic neuropathies cause chronic disabling loss of visual
function. The development of recombinant adeno-associated viral vectors (rAAV) gene …

Recent advances have driven the development of stem cell-derived, self-organizing, three-
dimensional miniature organs, termed organoids, which mimic different eye tissues …

During embryogenesis, optic vesicles develop from the diencephalon via a multistep
process of organogenesis. Using induced pluripotent stem cell (iPSC)-derived human brain …

Retinitis pigmentosa and Leber congenital amaurosis are inherited retinal dystrophies that
can be caused by mutations in the Crumbs homolog 1 (CRB1) gene. CRB1 is required for …

Human retinal organoids from induced pluripotent stem cells (hiPSCs) can be used to
confirm the localization of proteins in retinal cell types and to test transduction and …

CRB1 gene mutations can cause early-or late-onset retinitis pigmentosa, Leber congenital
amaurosis, or maculopathy. Recapitulating human CRB1 phenotypes in animal models has …

Retinitis pigmentosa (RP) is a group of genetic diseases that results in rod photoreceptor
cell degeneration, which subsequently leads to cone photoreceptor cell death, impaired …

The majority of patients with mutations in CRB1 develop either early-onset retinitis
pigmentosa as young children or Leber congenital amaurosis as newborns. The cause for …

Variations in the human Crumbs homolog-1 (CRB1) gene lead to an array of retinal
dystrophies including early onset of retinitis pigmentosa (RP) and Leber congenital …

The Crumbs complex has prominent roles in the control of apical cell polarity, in the coupling
of cell density sensing to downstream cell signaling pathways, and in regulating junctional …