During sepsis, a complex network of cytokine, immune, and endothelial cell interactions
occur and disturbances in the microcirculation cause organ dysfunction or even failure …

Background: The aim of tissue engineering is to repair and regenerate damaged organs
using a combination of cells, biomaterials and growth factors. Mesenchymal stem cells …

Background Bone marrow-derived mesenchymal stem cells (BMSCs) are a widely
researched adult stem cell population capable of differentiation into various lineages …

Understanding the mechanisms by which adult stem cells produce growth factors may
represent an important way to optimize their beneficial paracrine and autocrine effects …

Adipose-derived stem cells (ASCs) can self-renew and differentiate along multiple cell
lineages. ASCs are also potently anti-inflammatory due to their inherent ability to regulate …

Mesenchymal stem cell (MSC) therapy has gained significant traction in the context of
cardiovascular repair, and have been proposed to exert their regenerative effects via the …

As individuals age, the skin undergoes changes, such as irregular pigmentation, thinning
and loss of elasticity, that are due to both genetic and environmental factors. These changes …

Mesenchymal stem cells (MSCs) are a promising therapy for acute organ ischemia in part
due to their paracrine production of growth factors. However, transplanted cells encounter …

Importance of the field: Several lines of evidence suggest that VEGF is a key regulator of the
paracrine effects of adipose-derived stem cells (ASCs), but the mechanism of action remains …

Background Mesenchymal stem cells (MSC) improve alveolar and vascular structures in
experimental models of bronchopulmonary dysplasia (BPD). Female MSC secrete more anti …