Traumatic brain injury: mechanisms of glial response
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …
external forces. TBI is the main factor of death and morbidity in young males with a high …
Neuroimmunology of traumatic brain injury: time for a paradigm shift
YN Jassam, S Izzy, M Whalen, DB McGavern… - Neuron, 2017 - cell.com
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …
The far-reaching scope of neuroinflammation after traumatic brain injury
DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …
of clinical investigations and popular press coverage of athletes and veterans with single or …
Neuroinflammation: the devil is in the details
There is significant interest in understanding inflammatory responses within the brain and
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …
Microglia in the TBI brain: the good, the bad, and the dysregulated
As the major cellular component of the innate immune system in the central nervous system
(CNS) and the first line of defense whenever injury or disease occurs, microglia play a …
(CNS) and the first line of defense whenever injury or disease occurs, microglia play a …
Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics
ML Pearn, IR Niesman, J Egawa, A Sawada… - Cellular and molecular …, 2017 - Springer
Traumatic brain injury (TBI) is one of the leading causes of death of young people in the
developed world. In the United States alone, 1.7 million traumatic events occur annually …
developed world. In the United States alone, 1.7 million traumatic events occur annually …
Neuroinflammation and blood–brain barrier disruption following traumatic brain injury: pathophysiology and potential therapeutic targets
S Sulhan, KA Lyon, LA Shapiro… - Journal of neuroscience …, 2020 - Wiley Online Library
Abstract Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in
young adults and children in the developed world, occurring in over 1.7 million persons and …
young adults and children in the developed world, occurring in over 1.7 million persons and …
Microglial/macrophage polarization dynamics following traumatic brain injury
Activated microglia and macrophages exert dual beneficial and detrimental roles after
central nervous system injury, which are thought to be due to their polarization along a …
central nervous system injury, which are thought to be due to their polarization along a …
Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease
DM Norden, MM Muccigrosso, JP Godbout - Neuropharmacology, 2015 - Elsevier
Glia of the central nervous system (CNS) help to maintain homeostasis in the brain and
support efficient neuronal function. Microglia are innate immune cells of the brain that …
support efficient neuronal function. Microglia are innate immune cells of the brain that …
Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities
Y Xiong, A Mahmood, M Chopp - Chinese Journal of Traumatology, 2018 - mednexus.org
Traumatic brain injury (TBI) remains a major cause of death and disability worldwide.
Increasing evidence indicates that TBI is an important risk factor for neurodegenerative …
Increasing evidence indicates that TBI is an important risk factor for neurodegenerative …