Myosins are a large family of actin-based cytoskeletal motors that use energy derived from
ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have …

Much progress in understanding the evolution of new genes has been accomplished in the
past few years. Molecular mechanisms such as illegitimate recombination and LINE element …

We recently proposed a DNA replication–based mechanism of fork stalling and template
switching (FoSTeS) to explain the complex genomic rearrangements associated with a …

Mutations affecting the conversion of PI3P to the signaling lipid PI (3, 5) P2 result in
spongiform degeneration of mouse brain and are associated with the human disorders …

In hippocampal pyramidal cells, a small subset of dendritic spines contain endoplasmic
reticulum (ER). In large spines, ER frequently forms a spine apparatus, while smaller spines …

Class V myosins are one of the most ancient and widely distributed groups of the myosin
superfamily and are hypothesized to function as motors for actin-dependent organelle …

The identification of molecular motors that modulate the neuronal cytoskeleton has been
elusive. Here, we show that a molecular motor protein, myosin Va, is present in high …

Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity
within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) …

Class V myosins are actin-based motor proteins that have critical functions in organelle
trafficking. Of the three class V myosins expressed in mammals, relatively little is known …

Gene duplications alter the genetic constitution of organisms and can be a driving force of
molecular evolution in humans and the great apes. In this context, the study of genomic …