In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Various psychosocial factors have been implicated in the etiology and pathogenesis of
certain cardiovascular diseases such as atherosclerosis, now considered to be the result of …

Whereas the central nervous system (CNS) usually cannot regenerate, peripheral nerves
regenerate spontaneously after injury because of a permissive environment and activation …

The subject of neuroinflammation is reviewed. In response to psychological stress or certain
physical stressors, an inflammatory process may occur by release of neuropeptides …

Inflammatory substances play a part in the modu-lation of pain by interfering with nociceptive
transduction, conduction, and transmission. This modulation may result from alteration of the …

Regeneration of injured adult sensory neurons within the CNS is essentially abortive,
attributable in part to lesion-induced or revealed inhibitors such as the chondroitin sulfate …

Interleukin-6 (IL-6) is a multifunctional cytokine mediating inflammatory or immune reactions.
Here we investigated the possible role of IL-6 in the intact or lesioned peripheral nervous …

In previous studies, interleukin-6 was shown to be synthesized in approximately one-third of
lumbar dorsal root ganglion neurons during the first week after nerve transection. In present …

Study Design. This study was an exploratory repeated measures design comparing patients
undergoing two magnitudes of surgery in the lumbar spine: lumbar herniated disc repair and …

Interleukin-6 (IL-6) is a neuropoietic cytokine which is dramatically upregulated following
peripheral nerve injury at the site of injury, in the dorsal root ganglion (DRG) and in the …