Understanding and targeting cancer stem cells: therapeutic implications and challenges

K Chen, Y Huang, J Chen - Acta Pharmacologica Sinica, 2013 - nature.com
Cancer stem cells (CSCs) have been identified as rare cell populations in many cancers,
including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are …

CD133: molecule of the moment

D Mizrak, M Brittan, MR Alison - … of Pathology: A Journal of the …, 2008 - Wiley Online Library
Abstract CD133 (prominin‐1) was the first in a class of novel pentaspan membrane proteins
to be identified in both humans and mice, and was originally classified as a marker of …

Targeting cancer stem cells to overcome chemoresistance

T Nunes, D Hamdan, C Leboeuf… - International journal of …, 2018 - mdpi.com
Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer
heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant …

Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy

S Saigusa, K Tanaka, Y Toiyama, T Yokoe… - Annals of surgical …, 2009 - Springer
Background Cancer stem cells are associated with metastatic potential, treatment
resistance, and poor patient prognosis. Distant recurrence remains the major cause of …

CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer

S Maeda, H Shinchi, H Kurahara, Y Mataki… - British journal of …, 2008 - nature.com
Although CD133 has been shown to be a marker for cancer stem cells in various tumours, its
expression in pancreatic cancer has not yet been clinically reported. In this study, we …

CD44 and EpCAM: cancer-initiating cell markers

R Marhaba, P Klingbeil, T Nuebel… - Current molecular …, 2008 - ingentaconnect.com
Embryonic stem cells are immortal, can self renew, and differentiate into all cells of the body.
The adult organism maintains adult stem cells in regenerative organs that can differentiate …

[HTML][HTML] Circulating tumor and cancer stem cells in hepatitis C virus-associated liver disease

AA Bahnassy, ARN Zekri, A El-Bastawisy… - World Journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To assess the role of circulating tumor cells (CTCs) and cancer stem cells (CSCs) in
hepatitis C virus (HCV)-associated liver disease. METHODS: Blood and/or tissue samples …

Tumour-initiating cells vs. cancer 'stem'cells and CD133: what's in the name?

J Neuzil, M Stantic, R Zobalova, J Chladova… - Biochemical and …, 2007 - Elsevier
Recent evidence suggests that a subset of cells within a tumour have 'stem-
like'characteristics. These tumour-initiating cells, distinct from non-malignant stem cells …

Prostate cancer stem cells: the role of CD133

J Yang, O Aljitawi, P Van Veldhuizen - Cancers, 2022 - mdpi.com
Simple Summary The current theory of the prostate cancer stem cell (PCSC) may help us
understand cancer recurrence and treatment failure of prostate cancer, and CD133 is one of …

CD133, selectively targeting the root of cancer

JU Schmohl, DA Vallera - Toxins, 2016 - mdpi.com
Cancer stem cells (CSC) are capable of promoting tumor initiation and self-renewal, two
important hallmarks of carcinoma formation. This population comprises a small percentage …