Understanding and targeting cancer stem cells: therapeutic implications and challenges
K Chen, Y Huang, J Chen - Acta Pharmacologica Sinica, 2013 - nature.com
Cancer stem cells (CSCs) have been identified as rare cell populations in many cancers,
including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are …
including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are …
CD133: molecule of the moment
D Mizrak, M Brittan, MR Alison - … of Pathology: A Journal of the …, 2008 - Wiley Online Library
Abstract CD133 (prominin‐1) was the first in a class of novel pentaspan membrane proteins
to be identified in both humans and mice, and was originally classified as a marker of …
to be identified in both humans and mice, and was originally classified as a marker of …
Targeting cancer stem cells to overcome chemoresistance
Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer
heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant …
heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant …
Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy
S Saigusa, K Tanaka, Y Toiyama, T Yokoe… - Annals of surgical …, 2009 - Springer
Background Cancer stem cells are associated with metastatic potential, treatment
resistance, and poor patient prognosis. Distant recurrence remains the major cause of …
resistance, and poor patient prognosis. Distant recurrence remains the major cause of …
CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer
S Maeda, H Shinchi, H Kurahara, Y Mataki… - British journal of …, 2008 - nature.com
Although CD133 has been shown to be a marker for cancer stem cells in various tumours, its
expression in pancreatic cancer has not yet been clinically reported. In this study, we …
expression in pancreatic cancer has not yet been clinically reported. In this study, we …
CD44 and EpCAM: cancer-initiating cell markers
R Marhaba, P Klingbeil, T Nuebel… - Current molecular …, 2008 - ingentaconnect.com
Embryonic stem cells are immortal, can self renew, and differentiate into all cells of the body.
The adult organism maintains adult stem cells in regenerative organs that can differentiate …
The adult organism maintains adult stem cells in regenerative organs that can differentiate …
[HTML][HTML] Circulating tumor and cancer stem cells in hepatitis C virus-associated liver disease
AIM: To assess the role of circulating tumor cells (CTCs) and cancer stem cells (CSCs) in
hepatitis C virus (HCV)-associated liver disease. METHODS: Blood and/or tissue samples …
hepatitis C virus (HCV)-associated liver disease. METHODS: Blood and/or tissue samples …
Tumour-initiating cells vs. cancer 'stem'cells and CD133: what's in the name?
J Neuzil, M Stantic, R Zobalova, J Chladova… - Biochemical and …, 2007 - Elsevier
Recent evidence suggests that a subset of cells within a tumour have 'stem-
like'characteristics. These tumour-initiating cells, distinct from non-malignant stem cells …
like'characteristics. These tumour-initiating cells, distinct from non-malignant stem cells …
Prostate cancer stem cells: the role of CD133
J Yang, O Aljitawi, P Van Veldhuizen - Cancers, 2022 - mdpi.com
Simple Summary The current theory of the prostate cancer stem cell (PCSC) may help us
understand cancer recurrence and treatment failure of prostate cancer, and CD133 is one of …
understand cancer recurrence and treatment failure of prostate cancer, and CD133 is one of …
CD133, selectively targeting the root of cancer
JU Schmohl, DA Vallera - Toxins, 2016 - mdpi.com
Cancer stem cells (CSC) are capable of promoting tumor initiation and self-renewal, two
important hallmarks of carcinoma formation. This population comprises a small percentage …
important hallmarks of carcinoma formation. This population comprises a small percentage …