The nuclear pore complex as a flexible and dynamic gate
KE Knockenhauer, TU Schwartz - Cell, 2016 - cell.com
Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary
transport gates for molecular exchange between nucleus and cytoplasm. Stripping the …
transport gates for molecular exchange between nucleus and cytoplasm. Stripping the …
Mechanisms and functions of nuclear envelope remodelling
R Ungricht, U Kutay - Nature Reviews molecular cell biology, 2017 - nature.com
As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …
membrane shell for the genome and a versatile communication interface between the …
Identification of host proteins required for HIV infection through a functional genomic screen
AL Brass, DM Dykxhoorn, Y Benita, N Yan… - science, 2008 - science.org
HIV-1 exploits multiple host proteins during infection. We performed a large-scale small
interfering RNA screen to identify host factors required by HIV-1 and identified more than …
interfering RNA screen to identify host factors required by HIV-1 and identified more than …
Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells
MA D'Angelo, M Raices, SH Panowski, MW Hetzer - Cell, 2009 - cell.com
In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and
reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic …
reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic …
The structure of the nuclear pore complex
In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and
translation in the cytoplasm imposes the requirement of transporting thousands of …
translation in the cytoplasm imposes the requirement of transporting thousands of …
Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation
Nanobodies are single-domain antibodies of camelid origin. We generated nanobodies
against the vertebrate nuclear pore complex (NPC) and used them in STORM imaging to …
against the vertebrate nuclear pore complex (NPC) and used them in STORM imaging to …
Orchestrating nuclear envelope disassembly and reassembly during mitosis
S Güttinger, E Laurell, U Kutay - Nature reviews Molecular cell biology, 2009 - nature.com
Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …
A general amphipathic α-helical motif for sensing membrane curvature
G Drin, JF Casella, R Gautier, T Boehmer… - Nature structural & …, 2007 - nature.com
Abstract The Golgi-associated protein ArfGAP1 has an unusual membrane-adsorbing
amphipathic α-helix: its polar face is weakly charged, containing mainly serine and …
amphipathic α-helix: its polar face is weakly charged, containing mainly serine and …
The nuclear envelope
MW Hetzer - Cold Spring Harbor perspectives in biology, 2010 - cshperspectives.cshlp.org
The nuclear envelope (NE) is a highly regulated membrane barrier that separates the
nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different …
nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different …
Mapping the dynamic organization of the nuclear pore complex inside single living cells
Most cellular activities are executed by multi-protein complexes that form the basic functional
modules of their molecular machinery. Proteomic approaches can provide an evermore …
modules of their molecular machinery. Proteomic approaches can provide an evermore …