Quantitative phase imaging: recent advances and expanding potential in biomedicine
TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …
[HTML][HTML] Automation, monitoring, and standardization of cell product manufacturing
MN Doulgkeroglou, A Di Nubila, B Niessing… - … in Bioengineering and …, 2020 - frontiersin.org
Although regenerative medicine products are at the forefront of scientific research,
technological innovation, and clinical translation, their reproducibility and large-scale …
technological innovation, and clinical translation, their reproducibility and large-scale …
Quantitative scoring of epithelial and mesenchymal qualities of cancer cells using machine learning and quantitative phase imaging
Significance: We introduce an application of machine learning trained on optical phase
features of epithelial and mesenchymal cells to grade cancer cells' morphologies, relevant to …
features of epithelial and mesenchymal cells to grade cancer cells' morphologies, relevant to …
Raman and quantitative phase imaging allow morpho-molecular recognition of malignancy and stages of B-cell acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is one of the most common malignancies that account
for nearly one-third of all pediatric cancers. The current diagnostic assays are time …
for nearly one-third of all pediatric cancers. The current diagnostic assays are time …
Coarse Raman and optical diffraction tomographic imaging enable label-free phenotyping of isogenic breast cancer cells of varying metastatic potential
Identification of the metastatic potential represents one of the most important tasks for
molecular imaging of cancer. While molecular imaging of metastases has witnessed …
molecular imaging of cancer. While molecular imaging of metastases has witnessed …
Dual-modality digital holographic and polarization microscope to quantify phase and birefringence signals in biospecimens with a complex microstructure
Optical phase and birefringence signals occur in cells and thin, semi-transparent
biomaterials. A dual-modality quantitative phase and polarization microscope was designed …
biomaterials. A dual-modality quantitative phase and polarization microscope was designed …
Predicting quality decay in continuously passaged mesenchymal stem cells by detecting morphological anomalies
Y Takemoto, Y Imai, K Kanie, R Kato - Journal of bioscience and …, 2021 - Elsevier
Highlights•A sudden quality decay in continuously passaged MSCs can be detected only
from image.•Using morphological cell population visualization, quality decay can be …
from image.•Using morphological cell population visualization, quality decay can be …
[HTML][HTML] Classification and counting of cells in brightfield microscopy images: an application of convolutional neural networks
E Ferreira, GF Silveira - Scientific Reports, 2024 - nature.com
Microscopy is integral to medical research, facilitating the exploration of various biological
questions, notably cell quantification. However, this process's time-consuming and error …
questions, notably cell quantification. However, this process's time-consuming and error …
Morphology, motility, and cytoskeletal architecture of breast cancer cells depend on keratin 19 and substrate
Cancer cells gain motility through events that accompany modulation of cell shape and
include altered expression of keratins. However, the role of keratins in change of cancer cell …
include altered expression of keratins. However, the role of keratins in change of cancer cell …
Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells
ABSTRACT A cytoskeletal protein keratin 19 (K19) is highly expressed in breast cancer but
its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression …
its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression …