Conspectus DNA G-quadruplex secondary structures formed in guanine-rich human
telomeres and oncogene promoters are functionally important and have emerged as a …

Myc is an oncogene deregulated in most—perhaps all—human cancers. Each Myc family
member, c-, L-, and N-Myc, has been connected to tumor progression and maintenance …

G-quadruplexes are four-stranded DNA structures that are over-represented in gene
promoter regions and are viewed as emerging therapeutic targets in oncology, as …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

Hallmark deregulated signaling in cancer cells drives excessive ribosome biogenesis within
the nucleolus, which elicits unbridled cell growth and proliferation. The rate-limiting step of …

Over the past decade, nucleic acid chemists have seen the spectacular emergence of
molecules designed to interact efficiently and selectively with a peculiar DNA structure …

Unimolecular parallel-stranded G-quadruplex structures are found to be prevalent in gene
promoters. The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter can …

The importance of DNA supercoiling in transcriptional regulation has been known for many
years, and more recently, transcription itself has been shown to be a source of this …

Abstract G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the
promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s …

Quadruplex nucleic acids are four-stranded structures formed from short tracts of G-rich
sequence associating together. Their formation from eukaryotic telomeric DNA sequences is …