Machine perfusion of the liver: applications beyond transplantation
Abstract Machine perfusion (MP) is at the forefront of innovation in modern liver
transplantation. Several approaches, mainly varying the temperature at which the graft is …
transplantation. Several approaches, mainly varying the temperature at which the graft is …
Systematic evaluation of the safety threshold for allograft macrovesicular steatosis in cadaveric liver transplantation
Z Liu, J Jia, H Ning, S Que, L Zhou, S Zheng - Frontiers in Physiology, 2019 - frontiersin.org
Background: Currently, 30% macrovesicular steatosis (MaS) content is usually assigned
empirically as the boundary between “use” and “refuse” a donor liver for liver transplantation …
empirically as the boundary between “use” and “refuse” a donor liver for liver transplantation …
Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference
The assessment of liver steatosis is crucial in both hepatology and liver transplantation (LT)
surgery. Steatosis can negatively impact the success of LT. Steatosis is a factor for excluding …
surgery. Steatosis can negatively impact the success of LT. Steatosis is a factor for excluding …
[PDF][PDF] Early Allograft Dysfunction Increases Hospital Associated Costs After Liver Transplantation—A Propensity Score–Matched Analysis
S Moosburner, IM Sauer, F Förster… - Hepatology …, 2021 - Wiley Online Library
Concepts to ameliorate the continued mismatch between demand for liver allografts and
supply include the acceptance of allografts that meet extended donor criteria (ECD). ECD …
supply include the acceptance of allografts that meet extended donor criteria (ECD). ECD …
Efficiency of machine learning algorithms for the determination of macrovesicular steatosis in frozen sections stained with sudan to evaluate the quality of the graft in …
F Pérez-Sanz, M Riquelme-Pérez, E Martínez-Barba… - Sensors, 2021 - mdpi.com
Liver transplantation is the only curative treatment option in patients diagnosed with end-
stage liver disease. The low availability of organs demands an accurate selection procedure …
stage liver disease. The low availability of organs demands an accurate selection procedure …
Improvement of steatotic rat liver function with a defatting cocktail during ex situ normothermic machine perfusion is not directly related to liver fat content
There is a significant organ shortage in the field of liver transplantation, partly due to a high
discard rate of steatotic livers from donors. These organs are known to function poorly if …
discard rate of steatotic livers from donors. These organs are known to function poorly if …
Development of a rat liver machine perfusion system for normothermic and subnormothermic conditions
M Nösser, JMGV Gassner, S Moosburner… - … engineering Part A, 2020 - liebertpub.com
Ex vivo liver machine perfusion (MP) is a promising alternative for preservation of liver grafts
from extended criteria donors. Small animal models can be used to evaluate different …
from extended criteria donors. Small animal models can be used to evaluate different …
Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies
S Raigani, N Karimian, V Huang, AM Zhang, I Beijert… - PloS one, 2020 - journals.plos.org
There continues to be a significant shortage of donor livers for transplantation. One
impediment is the discard rate of fatty, or steatotic, livers because of their poor post …
impediment is the discard rate of fatty, or steatotic, livers because of their poor post …
Defatting of donor transplant livers during normothermic perfusion—a randomised clinical trial: study protocol for the DeFat study
SH Abbas, CDL Ceresa, L Hodson, D Nasralla… - Trials, 2024 - Springer
Background Liver disease is the third leading cause of premature death in the UK.
Transplantation is the only successful treatment for end-stage liver disease but is limited by …
Transplantation is the only successful treatment for end-stage liver disease but is limited by …
Multi-omics network analysis on samples from sequential biopsies reveals vital role of proliferation arrest for Macrosteatosis related graft failure in rats after liver …
Z Liu, W Wang, X Li, J Zhao, H Zhu, S Que, Y He, J Xu… - Genomics, 2023 - Elsevier
To investigate the molecular impact of graft MaS on post-transplant prognosis, based on
multi-omics integrative analysis. Rats were fed by methionine-choline deficient diet (MCD) …
multi-omics integrative analysis. Rats were fed by methionine-choline deficient diet (MCD) …