Costunolide—A bioactive sesquiterpene lactone with diverse therapeutic potential

DY Kim, BY Choi - International journal of molecular sciences, 2019 - mdpi.com
Sesquiterpene lactones constitute a major class of bioactive natural products. One of the
naturally occurring sesquiterpene lactones is costunolide, which has been extensively …

Phytochemical and pharmacological properties of Vernonia amygdalina: a review

OR Alara, NH Abdurahman… - Journal of Chemical …, 2017 - journal.ump.edu.my
Vernonia amygdalina has been a known food and medicinal plants used in Asia and Africa
(West Africa) due to its pharmacological effects (antioxidant, anti-diabetes, antiinflammatory …

A review of therapeutic potential of Saussurea lappa-An endangered plant from Himalaya

K Zahara, S Tabassum, S Sabir, M Arshad… - Asian Pacific journal of …, 2014 - Elsevier
There are 300 known Saussurea species. Among them, Saussurea lappa (S. lappa) is a
representative perennial herb, globally distributed across Himalaya region. S. lappa has …

Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone

X Lin, Z Peng, C Su - International journal of molecular sciences, 2015 - mdpi.com
Costunolide (CE) and dehydrocostuslactone (DE) are derived from many species of
medicinal plants, such as Saussurea lappa Decne and Laurus nobilis L. They have been …

Back to the roots—an overview of the chemical composition and bioactivity of selected root-essential oils

K Lunz, I Stappen - Molecules, 2021 - mdpi.com
Since ancient times, plant roots have been widely used in traditional medicine for treating
various ailments and diseases due to their beneficial effects. A large number of studies have …

Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm

V Duraipandiyan, N Abdullah Al-Harbi… - … and alternative medicine, 2012 - Springer
Abstract Background Costus speciosus (Koen ex. Retz.) Sm (Costaceae) is an Indian
ornamental plant which has long been used medicinally in traditional systems of medicine …

Reconstitution of the Costunolide Biosynthetic Pathway in Yeast and Nicotiana benthamiana

Q Liu, M Majdi, K Cankar, M Goedbloed… - PloS one, 2011 - journals.plos.org
The sesquiterpene costunolide has a broad range of biological activities and is the parent
compound for many other biologically active sesquiterpenes such as parthenolide. Two …

[HTML][HTML] Root extracts of Saussurea costus as prospective detoxifying food additive against sodium nitrite toxicity in male rats

SE Elshaer, GM Hamad, EE Hafez… - Food and Chemical …, 2022 - Elsevier
The goal of this study was to investigate the effects of three different extracts of Saussurea
costus roots (ethanol, methanol, and water) as a food additive in alleviating the harmful …

Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction

A Rasul, R Bao, M Malhi, B Zhao, I Tsuji, J Li, X Li - Molecules, 2013 - mdpi.com
Despite the availability of several therapeutic options, a safer and more effective modality is
urgently needed for treatment of bladder cancer. Costunolide, a member of sesquiterpene …

Dehydrocostus lactone inhibits Candida albicans growth and biofilm formation

J Zhang, J Sun, Y Zhang, M Zhang, X Liu, L Yang… - AMB Express, 2023 - Springer
Candida albicans infections are threatening public health but there are only several
antifungal drugs available. This study was to assess the effects of dehydrocostus lactone …