The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs
worldwide constitute a problem of crisis dimensions. The root causes of this problem are …

Sepsis is among the most common causes of death in hospitals. It arises from the host
response to infection. Currently, diagnosis relies on nonspecific physiological criteria and …

Background In critically ill patients, antibiotic therapy is of great importance but long duration
of treatment is associated with the development of antimicrobial resistance. Procalcitonin is …

The diagnostic use of procalcitonin for bacterial infections remains a matter of debate. Most
studies have used ambiguous outcome measures such as sepsis instead of infection. We …

Sepsis represents a major cause of lethality during intensive care unit (ICU) treatment.
Pharmacological treatment strategies for sepsis are still limited and mainly based on the …

Study Objective The neutrophil-lymphocyte count ratio (NLCR) has been identified as a
predictor of bacteremia in medical emergencies. The aim of this study was to investigate the …

Previous randomized controlled trials suggest that using clinical algorithms based on
procalcitonin levels, a marker of bacterial infections, results in reduced antibiotic use without …

Background Pneumonia is the most common hospital‐acquired infection affecting patients in
the intensive care unit (ICU). However, the optimal duration of antibiotic therapy for hospital …

Background. Procalcitonin algorithms may reduce antibiotic use for acute respiratory tract
infections (ARIs). We undertook an individual patient data meta-analysis to assess safety of …

Objective To date, there are no studies regarding the lactylation profile and its role in
critically ill patients. Thus, we aimed to examine expression of histone H3 lysine 18 (H3K18) …