Safety issues and prospects for future generations of PPAR modulators
A Rubenstrunk, R Hanf, DW Hum, JC Fruchart… - … et Biophysica Acta (BBA …, 2007 - Elsevier
Because of their wide range of actions on glucose homeostasis, lipid metabolism and
vascular inflammation, peroxisome proliferator-activated receptors (PPARs) are promising …
vascular inflammation, peroxisome proliferator-activated receptors (PPARs) are promising …
Homocysteine: role and implications in atherosclerosis
S Guthikonda, WG Haynes - Current atherosclerosis reports, 2006 - Springer
Hyperhomocysteinemia promotes atherosclerosis and is most commonly caused by B-
vitamin deficiencies, especially folic acid, B 6, and B 12; genetic disorders; certain drugs; …
vitamin deficiencies, especially folic acid, B 6, and B 12; genetic disorders; certain drugs; …
Hyperhomocysteinemia accelerates atherosclerosis in cystathionine β-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation
Although hyperhomocysteinemia is an independent risk factor for cardiovascular disease, a
direct role for homocysteine (Hcy) in this disease remains to be shown. Whereas diet …
direct role for homocysteine (Hcy) in this disease remains to be shown. Whereas diet …
Highly flexible and porous silk fibroin microneedle wraps for perivascular drug delivery
Various perivascular drug delivery techniques have been demonstrated for localized post-
treatment of intimal hyperplasia: a vascular inflammatory response caused by endothelial …
treatment of intimal hyperplasia: a vascular inflammatory response caused by endothelial …
Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms
J Zhou, RC Austin - Biofactors, 2009 - Wiley Online Library
Hyperhomocysteinemia (HHcy) is considered an independent risk factor for cardiovascular
disease, including ischemic heart disease, stroke, and peripheral vascular disease …
disease, including ischemic heart disease, stroke, and peripheral vascular disease …
Hyperhomocysteinemia, vascular function and atherosclerosis: effects of vitamins
WG Haynes - Cardiovascular Drugs and therapy, 2002 - Springer
Homocysteine is a metabolic product of methyl group donation by the amino acid
methionine. Moderate elevation of plasma homocysteine (> 15 μM) is most commonly …
methionine. Moderate elevation of plasma homocysteine (> 15 μM) is most commonly …
Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models
C Chen, ME Halkos, SM Surowiec, BS Conklin… - Journal of Surgical …, 2000 - Elsevier
Background. Hyperhomocysteinemia is associated with increased risk for vascular disease.
However, the pathogenic mechanisms of homocysteine are largely unknown. We evaluated …
However, the pathogenic mechanisms of homocysteine are largely unknown. We evaluated …
Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive rats
J Joseph, A Washington, L Joseph… - American Journal …, 2002 - journals.physiology.org
Hyperhomocysteinemia (Hhe), linked to cardiovascular disease by epidemiological studies,
may be an important factor in adverse cardiac remodeling in hypertension. Specifically …
may be an important factor in adverse cardiac remodeling in hypertension. Specifically …
Transfer-molded wrappable microneedle meshes for perivascular drug delivery
After surgical procedures such as coronary/peripheral bypass grafting or endarterectomy for
the treatment of organ ischemia derived from atherosclerosis, intimal hyperplasia (IH) which …
the treatment of organ ischemia derived from atherosclerosis, intimal hyperplasia (IH) which …
[HTML][HTML] Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia
H Kumagai, S Katoh, K Hirosawa, M Kimura… - Kidney international, 2002 - Elsevier
Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia. Background
While hyperhomocysteinemia is associated with an increased risk of atherosclerosis and the …
While hyperhomocysteinemia is associated with an increased risk of atherosclerosis and the …