The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Anaemia is a global public health problem affecting both developing and developed
countries with major consequences for human health as well as social and economic …

As medical advances improve survival, reduce disease-related morbidity, and improve
quality of life, reproductive issues will take higher priority in the sickle cell disease (SCD) …

Hemoglobinopathies, including β-thalassemia and sickle cell disease (SCD), are common
genetic blood disorders. Endocrine disorders are frequent manifestations of organ damage …

Background Recent progress in the treatment of sickle cell disease, in particular the use of
hydroxyurea, has considerably modified the prognosis of this disease. Many more patients …

Despite regular blood transfusion and desferrioxamine treatment, growth impairment and
pubertal delay are commonly seen in children and adolescents with transfusion-dependent …

Abstract Background Children with Sickle Cell Disease (SCD) show endocrine
complications and metabolic alterations. The physiopathology of these conditions is not …

Background: Poor growth and under-nutrition are common in children with sickle cell
disease (SCD). This review summarises evidence of nutritional status in children with SCD …

Male infertility is a widespread health problem affecting approximately 6%–8% of the male
population, and hypoxia may be a causative factor. In mammals, two types of hypoxia are …

This review provides an overview of reproductive and sexual healthcare concerns for
individuals with SCD and their families. Reproductive and sexual health care are …