Transient receptor potential (TRP) channels: Biosensors for redox environmental stimuli and cellular status

R Sakaguchi, Y Mori - Free Radical Biology and Medicine, 2020 - Elsevier
Transient receptor potential (TRP) channels are a family of cation channels that depolarizes
the membrane potential and regulates intracellular concentrations of cations such as Ca 2+ …

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

WZ Zeng, KL Marshall, S Min, I Daou, MW Chapleau… - Science, 2018 - science.org
Activation of stretch-sensitive baroreceptor neurons exerts acute control over heart rate and
blood pressure. Although this homeostatic baroreflex has been described for more than 80 …

Pharmacology of TRPC channels and its potential in cardiovascular and metabolic medicine

RS Bon, DJ Wright, DJ Beech… - Annual review of …, 2022 - annualreviews.org
Transient receptor potential canonical (TRPC) proteins assemble to form homo-or
heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC …

Remarkable progress with small-molecule modulation of TRPC1/4/5 channels: implications for understanding the channels in health and disease

A Minard, CC Bauer, DJ Wright, HN Rubaiy, K Muraki… - Cells, 2018 - mdpi.com
Proteins of the TRPC family can form many homo-and heterotetrameric cation channels
permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the …

Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy

P Thakore, JE Clark, AA Aubdool, D Thapa, A Starr… - Biomolecules, 2024 - mdpi.com
TRPC5 is a non-selective cation channel that is expressed in cardiomyocytes, but there is a
lack of knowledge of its (patho) physiological role in vivo. Here, we examine the role of …

Regulation of cardiac function by the autonomic nervous system

OA Hafez, RB Chang - Physiology, 2024 - journals.physiology.org
The autonomic nervous system is critical for regulating cardiovascular physiology. The
neurocardiac axis encompasses multiple levels of control, including the motor circuits of the …

Canonical transient receptor potential 3 channels in atrial fibrillation

L Han, J Li - European Journal of Pharmacology, 2018 - Elsevier
The pathogenesis of atrial fibrillation (AF) is largely dependent on structural remodeling and
electrical reconfiguration, which in turn drive localized fibrosis. Canonical transient receptor …

[HTML][HTML] TRPC5 expression promotes the proliferation and invasion of papillary thyroid carcinoma through the HIF-1α/Twist pathway

J Yang, Y Cheng, Y Nie, B Tian, J Huang, R Gong… - Translational …, 2024 - Elsevier
Objective This study aimed to investigate the effect of TRPC5 on PTC (papillary thyroid
carcinoma) proliferation and invasion. Methods Immunofluorescence and western blot were …

Neuronal stretch reception–Making sense of the mechanosense

R Das, S Wieser, M Krieg - Experimental Cell Research, 2019 - Elsevier
The sensation of mechanical force underlies many of our daily activities. As the sense of
touch determines the quality of life, the subconscious sense of proprioception and visceral …

Correspondence: Reply to 'Challenging a proposed role for TRPC5 in aortic baroreceptor pressure-sensing'

OC Lau, B Shen, CO Wong, X Yao - Nature communications, 2018 - nature.com
We originally reported that the mean arterial pressure in Trpc5−/− mice was higher than in
wild-type mice, which differs from observations made by Thakore et al. 2 Upon re …