Transient receptor potential (TRP) channels: Biosensors for redox environmental stimuli and cellular status
R Sakaguchi, Y Mori - Free Radical Biology and Medicine, 2020 - Elsevier
Transient receptor potential (TRP) channels are a family of cation channels that depolarizes
the membrane potential and regulates intracellular concentrations of cations such as Ca 2+ …
the membrane potential and regulates intracellular concentrations of cations such as Ca 2+ …
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
Activation of stretch-sensitive baroreceptor neurons exerts acute control over heart rate and
blood pressure. Although this homeostatic baroreflex has been described for more than 80 …
blood pressure. Although this homeostatic baroreflex has been described for more than 80 …
Pharmacology of TRPC channels and its potential in cardiovascular and metabolic medicine
RS Bon, DJ Wright, DJ Beech… - Annual review of …, 2022 - annualreviews.org
Transient receptor potential canonical (TRPC) proteins assemble to form homo-or
heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC …
heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC …
Remarkable progress with small-molecule modulation of TRPC1/4/5 channels: implications for understanding the channels in health and disease
Proteins of the TRPC family can form many homo-and heterotetrameric cation channels
permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the …
permeable to Na+, K+ and Ca2+. In this review, we focus on channels formed by the …
Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy
TRPC5 is a non-selective cation channel that is expressed in cardiomyocytes, but there is a
lack of knowledge of its (patho) physiological role in vivo. Here, we examine the role of …
lack of knowledge of its (patho) physiological role in vivo. Here, we examine the role of …
Regulation of cardiac function by the autonomic nervous system
OA Hafez, RB Chang - Physiology, 2024 - journals.physiology.org
The autonomic nervous system is critical for regulating cardiovascular physiology. The
neurocardiac axis encompasses multiple levels of control, including the motor circuits of the …
neurocardiac axis encompasses multiple levels of control, including the motor circuits of the …
Canonical transient receptor potential 3 channels in atrial fibrillation
L Han, J Li - European Journal of Pharmacology, 2018 - Elsevier
The pathogenesis of atrial fibrillation (AF) is largely dependent on structural remodeling and
electrical reconfiguration, which in turn drive localized fibrosis. Canonical transient receptor …
electrical reconfiguration, which in turn drive localized fibrosis. Canonical transient receptor …
[HTML][HTML] TRPC5 expression promotes the proliferation and invasion of papillary thyroid carcinoma through the HIF-1α/Twist pathway
J Yang, Y Cheng, Y Nie, B Tian, J Huang, R Gong… - Translational …, 2024 - Elsevier
Objective This study aimed to investigate the effect of TRPC5 on PTC (papillary thyroid
carcinoma) proliferation and invasion. Methods Immunofluorescence and western blot were …
carcinoma) proliferation and invasion. Methods Immunofluorescence and western blot were …
Neuronal stretch reception–Making sense of the mechanosense
The sensation of mechanical force underlies many of our daily activities. As the sense of
touch determines the quality of life, the subconscious sense of proprioception and visceral …
touch determines the quality of life, the subconscious sense of proprioception and visceral …
Correspondence: Reply to 'Challenging a proposed role for TRPC5 in aortic baroreceptor pressure-sensing'
We originally reported that the mean arterial pressure in Trpc5−/− mice was higher than in
wild-type mice, which differs from observations made by Thakore et al. 2 Upon re …
wild-type mice, which differs from observations made by Thakore et al. 2 Upon re …