The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications

P Du, N Paskaranandavadivel… - … Systems Biology and …, 2016 - Wiley Online Library
The intestine comprises a long hollow muscular tube organized in anatomically and
functionally discrete compartments, which digest and absorb nutrients and water from …

The effect of chronic nausea on gastric slow wave spatiotemporal dynamics in children

S Somarajan, ND Muszynski, JD Olson… - …, 2021 - Wiley Online Library
Background Chronic nausea in adolescents with functional gastrointestinal disorders is an
increasingly reported but poorly understood symptom that negatively affects quality of life …

Diabetic gastroparesis alters the biomagnetic signature of the gastric slow wave

LA Bradshaw, LK Cheng, E Chung… - …, 2016 - Wiley Online Library
Background Gastroparesis is characterized by delayed gastric emptying without mechanical
obstruction, but remains difficult to diagnose and distinguish from other gastrointestinal (GI) …

Advancing peristalsis deciphering in mouse small intestine by multi-parameter tracking

A Sasidharan, BA Peethambar, KS Kumar… - Communications …, 2023 - nature.com
Assessing gastrointestinal motility lacks simultaneous evaluation of intraluminal pressure
(ILP), circular muscle (CM) and longitudinal muscle (LM) contraction, and lumen emptying …

Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea

S Somarajan, ND Muszynski… - American Journal …, 2022 - journals.physiology.org
Chronic nausea is a widespread functional disease in children with numerous comorbidities.
High-resolution electrogastrogram (HR-EGG) has shown sufficient sensitivity as a …

On the electrical intestine turbulence induced by temperature changes

A Gizzi, C Cherubini, S Migliori, R Alloni… - Physical …, 2010 - iopscience.iop.org
Paralytic ileus is a temporary syndrome with impairment of peristalsis and no passage of
food through the intestine. Although improvements in supportive measures have been …

Magnetic Active Agent Release System (MAARS): evaluation of a new way for a reproducible, externally controlled drug release into the small intestine

CT Dietzel, H Richert, S Abert, U Merkel… - Journal of controlled …, 2012 - Elsevier
Human absorption studies are used to test new drug candidates for their bioavailability in
different regions of the gastrointestinal tract. In order to replace invasive techniques (eg oral …

Electroanatomical mapping of the stomach with simultaneous biomagnetic measurements

CE Drake, LK Cheng, ND Muszynski… - Computers in Biology …, 2023 - Elsevier
Gastric motility is coordinated by bioelectric slow waves (SWs) and dysrhythmic SW activity
has been linked with motility disorders. Magnetogastrography (MGG) is the non-invasive …

Noninvasive biomagnetic detection of intestinal slow wave dysrhythmias in chronic mesenteric ischemia

S Somarajan, ND Muszynski… - American Journal …, 2015 - journals.physiology.org
Chronic mesenteric ischemia (CMI) is a challenging clinical problem that is difficult to
diagnose noninvasively. Diagnosis early in the disease process would enable life-saving …

Characterization of electrophysiological propagation by multichannel sensors

LA Bradshaw, JH Kim, S Somarajan… - IEEE Transactions …, 2015 - ieeexplore.ieee.org
Objective: The propagation of electrophysiological activity measured by multichannel
devices could have significant clinical implications. Gastric slow waves normally propagate …