A systematic review on rho-kinase as a potential therapeutic target for the treatment of erectile dysfunction

KA Zewdie, MA Ayza, BA Tesfaye… - … and Reports in …, 2020 - Taylor & Francis
Background Erectile dysfunction (ED) is a common clinical condition with limited treatment
options. The main aim of the present systematic review was to synthesize information on …

Tadalafil treatment improves cardiac, renal and lower urinary tract dysfunctions in rats with heart failure

AG Mora, DR Andrade, SC Janussi, TT Goncalves… - Life Sciences, 2022 - Elsevier
Abstract Tadalafil, a phosphodiesterase-5 (PDE5) inhibitor, shown to exert a protection to
heart failure (HF) associated damage or lower urinary tract symptoms (LUTS). Thus, we …

Causal association of cardiovascular disease with erectile dysfunction: a two‐sample bidirectional Mendelian randomization analysis

M Ye, J Chen, J Ma, J Wang, C Zhang, B Chen… - …, 2023 - Wiley Online Library
Background The association between cardiovascular diseases (CVD), including ischemic
stroke (IS), heart failure (HF), myocardial infarction (MI), and coronary heart disease (CHD) …

Physical exercise in the management of erectile dysfunction in patients with heart failure

A Gonzáles, T Carvalho, L Andreato, S Sties… - International Journal of …, 2019 - SciELO Brasil
Erectile dysfunction (ED) is a highly prevalent problem that affects the quality of life,
prognosis and survival of patients with heart failure (HF). In the management of ED, physical …

[HTML][HTML] Prenatal exposure to dibutyl phthalate contributes to erectile dysfunction in offspring male rats by activating the RhoA/ROCK signalling pathway

S Liu, J Li, W Wang, Y Zhang, S Li, T Li, J Jiang, F Zhao - Toxicology, 2024 - Elsevier
Prenatal exposure to dibutyl phthalate (DBP) has been reported to cause erectile
dysfunction (ED) in adult offspring rats. However, its underlying mechanisms are not fully …

Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP

J Blanco-Rivero, GK Couto, SM Paula… - American Journal …, 2021 - journals.physiology.org
Heart failure (HF) is associated with neurohumoral activation, which in turn leads to an
increased peripheral resistance. In mesenteric vasculature, perivascular innervation plays …

Impaired corpus cavernosum relaxation is accompanied by increased oxidative stress and up-regulation of the rho-kinase pathway in diabetic (Db/Db) mice

FBM Priviero, HAF Toque, KP Nunes, DG Priolli… - PLoS …, 2016 - journals.plos.org
Basal release of nitric oxide from endothelial cells modulates contractile activity in the
corpus cavernosum via inhibition of the RhoA/Rho-kinase signaling pathway. We aimed to …

Ex vivo Akt inhibition reverses castration induced internal pudendal artery and penile endothelial dysfunction

MR Odom, ES Pak, JL Hannan - Life sciences, 2021 - Elsevier
Aims Androgen deprivation therapy is a common prostate cancer treatment which causes
men to have castrate levels of testosterone. Unfortunately, most testosterone deficient …

[HTML][HTML] Sexual functions following cardiac resynchronization therapy: evaluation of male patients and their partners

HF Oncel, R Salar, ÖF Cicek - Cureus, 2023 - ncbi.nlm.nih.gov
Introduction: Sexual functionality, a critical component of health-related quality of life, can
decline for various reasons, including heart failure (HF). Our purpose was to prospectively …

Causal association between cardiovascular diseases and erectile dysfunction, a Mendelian randomization study

Q Li, Q Long, B Ren, S Bing - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Background Cardiovascular diseases (CVD), including coronary heart disease (CHD), heart
failure, ischemic heart disease (IHD), and atrial fibrillation, are prevalent in the aged …