Depletion of nicotinamide adenine dinucleotide (NAD+), a central redox cofactor and the
substrate of key metabolic enzymes, is the causative factor of a number of inherited and …

Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response
to acute and chronic injury. To adequately respond to constant changes in the environment …

Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical
function. However, the underlying molecular processes and how (lack of) physical activity is …

Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor in mammals and
microbes. Here we use isotope tracing to investigate the precursors supporting NAD …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere
protein-encoding genes (ie genotype-positive HCM). In an increasing number of patients …

Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a
substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and …

Alterations in cellular nicotinamide adenine dinucleotide (NAD+) levels have been observed
in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that …

Recent research has unveiled an expansive role of NAD+ in cellular energy generation,
redox reactions, and as a substrate or cosubstrate in signaling pathways that regulate health …

Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide
(NAD+) is involved in an extensive spectrum of human pathologies, including …

Dietary vitamin B3 components, such as nicotinamide and nicotinic acid, are precursors to
the ubiquitous redox cofactor nicotinamide adenine dinucleotide (NAD+). NAD+ levels are …