Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous
cellular processes, and several PTPs have been validated as therapeutic targets for human …

The understanding of the role of vanadium enzymes and of vanadium compounds (VCs) in
biology, as well as the design of new vanadium-based species for catalysis, materials …

Biosensors are powerful tools for detecting, real-time imaging, and quantifying molecules,
but rapidly constructing diverse genetically encoded biosensors remains challenging. Here …

Hydroxyl radical protein footprinting (HRPF) in combination with mass spectrometry reveals
the relative solvent exposure of labeled residues within a protein, thereby providing insight …

Protein tyrosine phosphatases (PTPs) play major roles in cancer and are emerging as
therapeutic targets. Recent reports suggest low–molecular weight PTP (LMPTP)—encoded …

Early TCR signaling is dependent on rapid phosphorylation and dephosphorylation of
multiple signaling and adaptor proteins, leading to T cell activation. This process is tightly …

Celastrol is a natural pentacyclic triterpene used in traditional Chinese medicine with
significant weight-lowering effects. Celastrol-administered mice at 100 μg/kg decrease food …

Background Astragalus membranaceus refers to a type of traditional Chinese medicine
(TCM) used to treat type 2 diabetes mellitus (T2DM), whereas its molecular mechanism …

The increased prevalence of chronic metabolic disorders, including obesity and type 2
diabetes and their associated comorbidities, are among the world's greatest health and …