Biochemical and biological attributes of matrix metalloproteinases
N Cui, M Hu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …
Matrix metalloproteinases, vascular remodeling, and vascular disease
X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
The role of matrix metalloproteinases in the epithelial‐mesenchymal transition of hepatocellular carcinoma
C Scheau, IA Badarau, R Costache… - Analytical cellular …, 2019 - Wiley Online Library
The epithelial‐mesenchymal transition (EMT) is a transformation process mandatory for the
local and distant progression of many malignant tumors, including hepatocellular carcinoma …
local and distant progression of many malignant tumors, including hepatocellular carcinoma …
[HTML][HTML] Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer
Matrix metalloproteinases (MMPs) have been implicated in diverse roles in breast cancer
development and progression. While many of the different MMPs expressed in breast cancer …
development and progression. While many of the different MMPs expressed in breast cancer …
TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway
G Song, S Xu, H Zhang, Y Wang, C Xiao… - Journal of Experimental …, 2016 - Springer
Background Tissue inhibitor matrix metalloproteinase 1 (TIMP1) plays a vital role in
carcinogenesis, yet its precise functional roles and regulation remain unclear. In this study …
carcinogenesis, yet its precise functional roles and regulation remain unclear. In this study …
Matrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disorders
J Liu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
[HTML][HTML] Mechanisms of lower extremity vein dysfunction in chronic venous disease and implications in management of varicose veins
JD Raffetto, RA Khalil - Vessel plus, 2021 - ncbi.nlm.nih.gov
Chronic venous disease (CVD) is a common venous disorder of the lower extremities. CVD
can be manifested as varicose veins (VVs), with dilated and tortuous veins, dysfunctional …
can be manifested as varicose veins (VVs), with dilated and tortuous veins, dysfunctional …
Therapeutic potential of matrix metalloproteinase inhibition in breast cancer
ES Radisky… - Journal of cellular …, 2017 - Wiley Online Library
Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that cleave nearly all
components of the extracellular matrix as well as many other soluble and cell‐associated …
components of the extracellular matrix as well as many other soluble and cell‐associated …
[HTML][HTML] Matrix metalloproteinases as breast cancer drivers and therapeutic targets
ES Radisky, DC Radisky - Frontiers in bioscience (Landmark …, 2015 - ncbi.nlm.nih.gov
Members of the matrix metalloproteinase (MMP) family have been identified as poor
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
Insights into the role of matrix metalloproteinases in precancerous conditions and in colorectal cancer
Z Pezeshkian, S Nobili, N Peyravian, B Shojaee… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer (CRC) is one of the most common cancer worldwide.
CRC is derived from polyps and many factors, such as Matrix Metalloproteinases (MMPs) …
CRC is derived from polyps and many factors, such as Matrix Metalloproteinases (MMPs) …