Wallerian axonal degeneration (WD) does not occur in the nematode C. elegans, in contrast
to other model animals. However, WD depends on the NADase activity of SARM1, a protein …

Innate immunity in bacteria, plants, and animals requires the specialized subset of
Toll/interleukin-1/resistance gene (TIR) domain proteins that are nicotinamide adenine …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
symptoms such as bradykinesia, resting tremor, and rigidity, primarily driven by the …

Introduction The degeneration of injured axons is driven by conserved molecules, including
the sterile armadillo TIR domain-containing protein SARM1, the cJun N-terminal kinase JNK …

We evaluated whether inhibiting sterile alpha and (Toll/interleukin receptor (TIR)) motif-
containing 1 (SARM1) activity protects retinal ganglion cells (RGCs) following ischemic …

SARM1 is a Toll-IL-1 receptor (TIR) domain-containing protein with roles in innate immunity
and neuronal death in diverse organisms. Unlike other innate immune TIR proteins that …

Injured nervous systems are often incapable of self-repairing, resulting in permanent loss of
function and disability. To restore function, a severed axon must not only regenerate, but …

Upon peripheral nervous system (PNS) injury, severed axons undergo rapid SARM1-
dependent Wallerian degeneration (WD). In mammals, the role of SARM1 in PNS …

Innate immunity in bacteria, plants and animals requires the specialized subset of TIR-
domain proteins that are NAD+ hydrolases. Aggregation of these TIR proteins engages their …

Nerve injury often leads to degeneration or necrosis of damaged nerve cells, which can
result in regeneration disorders during the repair process. Promoting nerve regeneration is a …