The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity.
Perturbations in either system can prompt primary pathological end points of hemorrhage or …

Fibrinogen is an extraordinary molecule by any estimation. It is large, structurally intricate,
and circulates at high concentrations. Its biological end product, insoluble fibrin (ogen) or …

Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI). The
impact of the gut microbiota and associated metabolites on APAP and liver function remains …

Acetaminophen (APAP)-induced liver injury (AILI) has become a growing public health
problem. Ferroptosis, an iron-dependent form of cell death associated with lipid peroxide …

Coagulation and the immune system interact in several physiological and pathological
conditions, including tissue repair, host defense, and homeostatic maintenance. This …

Liver is the primary source of numerous proteins that are critical for normal function of the
blood coagulation cascade. Because of this, diseases of the liver, particularly when affiliated …

Background & Aim Acetaminophen (APAP)-induced acute liver failure is associated with
substantial alterations in the hemostatic system. In mice, platelets accumulate in the liver …

Background & Aims Acetaminophen (APAP)-induced liver injury is coupled with activation of
the blood coagulation cascade and fibrin (ogen) accumulation within APAP-injured livers of …

Background Patients with acetaminophen (APAP)-induced acute liver failure (ALF) display
both hyper-and hypocoagulable changes not necessarily recapitulated by standard …

Summary In this Grand Round presentation, the case of a man with decompensated liver
disease is described. He subsequently developed a fatal pulmonary embolism, which may …