Impairment of glycolysis-derived l-serine production in astrocytes contributes to cognitive deficits in Alzheimer's disease
Alteration of brain aerobic glycolysis is often observed early in the course of Alzheimer's
disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic …
disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic …
Translation of preclinical PET imaging findings: Challenges and motion correction to overcome the confounding effect of anesthetics
Preclinical brain positron emission tomography (PET) in animals is performed using
anesthesia to avoid movement during the PET scan. In contrast, brain PET scans in humans …
anesthesia to avoid movement during the PET scan. In contrast, brain PET scans in humans …
Detection of amyloid plaques targeted by USPIO-Aβ1–42 in Alzheimer's disease transgenic mice using magnetic resonance microimaging
J Yang, YZ Wadghiri, DM Hoang, W Tsui, Y Sun… - Neuroimage, 2011 - Elsevier
Amyloid plaques are one of the pathological hallmarks of Alzheimer's disease (AD). The
visualization of amyloid plaques in the brain is important to monitor AD progression and to …
visualization of amyloid plaques in the brain is important to monitor AD progression and to …
Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer's disease transgenic mice using magnetic resonance microimaging
YZ Wadghiri, J Li, J Wang, DM Hoang, Y Sun, H Xu… - PloS one, 2013 - journals.plos.org
Amyloid plaques are a key pathological hallmark of Alzheimer's disease (AD). The detection
of amyloid plaques in the brain is important for the diagnosis of AD, as well as for following …
of amyloid plaques in the brain is important for the diagnosis of AD, as well as for following …
Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice
V Zerbi, M Wiesmann, TL Emmerzaal… - Journal of …, 2014 - Soc Neuroscience
It is well established that the cholesterol-transporter apolipoprotein ε (APOE) genotype is
associated with the risk of developing neurodegenerative diseases. Recently, brain …
associated with the risk of developing neurodegenerative diseases. Recently, brain …
Gray and white matter degeneration revealed by diffusion in an Alzheimer mouse model
V Zerbi, M Kleinnijenhuis, X Fang, D Jansen… - Neurobiology of …, 2013 - Elsevier
In patients with Alzheimer's disease (AD) the severity of white matter degeneration
correlates with the clinical symptoms of the disease. In this study, we performed diffusion …
correlates with the clinical symptoms of the disease. In this study, we performed diffusion …
Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimer's disease
V Zerbi, D Jansen, M Wiesmann, X Fang… - Neurobiology of …, 2014 - Elsevier
Nutritional intervention may retard the development of Alzheimer's disease (AD). In this
study we tested the effects of 2 multi-nutrient diets in an AD mouse model (APP swe/PS1 …
study we tested the effects of 2 multi-nutrient diets in an AD mouse model (APP swe/PS1 …
[HTML][HTML] Tensor image registration library: Deformable registration of stand‐alone histology images to whole‐brain post‐mortem MRI data
IN Huszar, M Pallebage-Gamarallage… - Neuroimage, 2023 - Elsevier
Background Accurate registration between microscopy and MRI data is necessary for
validating imaging biomarkers against neuropathology, and to disentangle complex signal …
validating imaging biomarkers against neuropathology, and to disentangle complex signal …
Validation of MRI-based 3D digital atlas registration with histological and autoradiographic volumes: an anatomofunctional transgenic mouse brain imaging study
J Lebenberg, AS Hérard, A Dubois, J Dauguet… - Neuroimage, 2010 - Elsevier
Murine models are commonly used in neuroscience to improve our knowledge of disease
processes and to test drug effects. To accurately study neuroanatomy and brain function in …
processes and to test drug effects. To accurately study neuroanatomy and brain function in …
Neurodegenerative changes in the brains of the 5xFAD Alzheimer's disease model mice investigated by high-field and high-resolution magnetic resonance imaging …
This study aimed to investigate morphological and metabolic changes in the brains of
5xFAD mice. Structural magnetic resonance imaging (MRI) and 1H magnetic resonance …
5xFAD mice. Structural magnetic resonance imaging (MRI) and 1H magnetic resonance …