Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In
the past decade, development of the new magnetic resonance imaging technique …

Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Huntington's disease is characterized by a triad of motor, cognitive and psychiatric
impairments, as well as unintended weight loss. Although much of the research has focused …

The age at onset of motor symptoms in Huntington's disease (HD) is driven by HTT CAG
repeat length but modified by other genes. In this study, we used exome sequencing of 683 …

SIGNAL is a multicenter, randomized, double-blind, placebo-controlled phase 2 study (no.
NCT02481674) established to evaluate pepinemab, a semaphorin 4D (SEMA4D)-blocking …

Significant progress has been made in understanding the pre-symptomatic phase of
amyotrophic lateral sclerosis. While much is still unknown, advances in other …

Background Although the association between cytosine-adenine-guanine (CAG) repeat
length and age at onset of Huntington's disease is well known, improved prediction of onset …

Huntington's disease is an inherited, degenerative brain disease, characterized by
involuntary movements, cognitive disorder and neuropsychiatric change. Men and women …

Background The study of complex neurodegenerative diseases is moving away from
hypothesis‐driven biological methods toward large scale multimodal approaches, requiring …