Much progress has been made toward deciphering RHO GTPase functions, and many
studies have convincingly demonstrated that altered signal transduction through RHO …

Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that
affects between 5 and 10% of the general population worldwide. The current symptom …

Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …

The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and probably
involves genetic predisposition and the effect of environmental factors. Unlike other …

The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …

Genetic studies of autism spectrum disorder (ASD) have revealed multigene variations that
converge on synaptic dysfunction. DOCK4, a gene at 7q31. 1 that encodes the Rac1 …

Rho family guanosine triphosphatases (GTPases) regulate cellular signaling and
cytoskeletal dynamics, playing a pivotal role in cell adhesion, migration, and cell cycle …

Mechanisms underlying the protective effect of apolipoprotein E (APOE) ε2 against
Alzheimer disease (AD) are not well understood. We analyzed gene expression data …

The Rho family GTPases are small G proteins that act as molecular switches shuttling
between active and inactive forms. Rho GTPases are regulated by two classes of regulatory …

Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide and
prognosis after potentially curative gastrectomy remains poor. Administration of GC-targeting …