Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Excitation-contraction coupling (ECC) is a physiological process that links excitation of
muscles by the nervous system to their mechanical contraction. In skeletal muscle, ECC is …

In skeletal muscle tissue, an intriguing mechanical coupling exists between two ion
channels from different membranes: the L-type voltage-gated calcium channel (Ca V 1.1) …

Ryanodine receptors (RyRs) are main regulators of intracellular Ca2+ release and muscle
contraction. The Y522S mutation of RyR1 causes central core disease, a weakening …

In skeletal muscle, residues 720–764/5 within the CaV1. 1 II–III loop form a critical domain
that plays an essential role in transmitting the excitation–contraction (EC) coupling Ca2+ …

In skeletal muscle, excitation–contraction (EC) coupling relies on the transmission of an
intermolecular signal from the voltage-sensing regions of the L-type Ca2+ channel (CaV1. 1) …

The core skeletal muscle ryanodine receptor (RyR1) calcium release complex extends
through three compartments of the muscle fibre, linking the extracellular environment …

One of the most important functions of skeletal muscle is to respond to nerve stimuli by
contracting. This function ensures body movement but also participates in other important …

Previous studies have reported that long, non‑coding RNAs (lncRNAs) are important in
cardiovascular disease. However, the lncRNAs involved in myocardial infarction and their …

Background The appearance of stimulant-class new psychoactive substances (NPS) is a
frequent and significant problem in our society. Cathinone variants are often sold illegally as …