Monitoring and measuring autophagy

SR Yoshii, N Mizushima - International journal of molecular sciences, 2017 - mdpi.com
Autophagy is a cytoplasmic degradation system, which is important for starvation adaptation
and cellular quality control. Recent advances in understanding autophagy highlight its …

Autophagy in the eye: development, degeneration, and aging

P Boya, L Esteban-Martínez, A Serrano-Puebla… - Progress in retinal and …, 2016 - Elsevier
Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular
components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes …

[HTML][HTML] Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's Disease

L La Barbera, F Vedele, A Nobili, P Krashia… - Progress in …, 2021 - Elsevier
What happens precociously to the brain destined to develop Alzheimer's Disease (AD) still
remains to be elucidated and this is one reason why effective AD treatments are missing …

TFEB biology and agonists at a glance

M Chen, Y Dai, S Liu, Y Fan, Z Ding, D Li - Cells, 2021 - mdpi.com
Autophagy is a critical regulator of cellular survival, differentiation, development, and
homeostasis, dysregulation of which is associated with diverse diseases including cancer …

β-Cell Autophagy in Diabetes Pathogenesis

MR Marasco, AK Linnemann - Endocrinology, 2018 - academic.oup.com
Nearly 100 years have passed since Frederick Banting and Charles Best first discovered
and purified insulin. Their discovery and subsequent improvements revolutionized the …

Methods for measuring autophagy in mice

M Moulis, C Vindis - Cells, 2017 - mdpi.com
Autophagy is a dynamic intracellular process that mediates the degradation of damaged
cytoplasmic components by the lysosome. This process plays important roles in maintaining …

The temporal pattern, flux, and function of autophagy in spinal cord injury

K Zhou, CA Sansur, H Xu, X Jia - International journal of molecular …, 2017 - mdpi.com
Previous studies have indicated that autophagy plays a critical role in spinal cord injury
(SCI), including traumatic spinal cord injury (TSCI) and ischemia-reperfusion spinal cord …

Neuronal death after perinatal cerebral hypoxia-ischemia: Focus on autophagy—mediated cell death

C Descloux, V Ginet, PGH Clarke, J Puyal… - International Journal of …, 2015 - Elsevier
Neonatal hypoxic-ischemic encephalopathy is a critical cerebral event occurring around
birth with high mortality and neurological morbidity associated with long-term invalidating …

Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function

ML Arotcarena, FN Soria, A Cunha, E Doudnikoff… - Aging …, 2022 - Wiley Online Library
Parkinson's disease (PD) is an age‐related neurodegenerative disorder characterized by
the loss of dopaminergic neurons in the substantia nigra, associated with the accumulation …

PP2C phosphatases Ptc1 and Ptc2 dephosphorylate PGK1 to regulate autophagy and aflatoxin synthesis in the pathogenic fungus Aspergillus flavus

Z Zhu, M Yang, G Yang, B Zhang, X Cao, J Yuan, F Ge… - Mbio, 2023 - Am Soc Microbiol
Reversible phosphorylation by protein kinases and phosphatases plays a central role in
regulating cellular processes. However, knowledge of the functions of protein phosphatase …