The prefrontal cortex (PFC)—the most evolved brain region—subserves our highest-order
cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental …

Pharmacological data clearly indicate that both muscarinic and nicotinic acetylcholine
receptors have a role in the encoding of new memories. Localized lesions and antagonist …

As indicated by the profound cognitive impairments caused by cholinergic receptor
antagonists, cholinergic neurotransmission has a vital role in cognitive function, specifically …

The neocortex generates periods of recurrent activity, such as the slow (0.1–0.5 Hz)
oscillation during slow-wave sleep. Here we demonstrate that slices of ferret neocortex …

Stimulus-specific persistent neural activity is the neural process underlying active (working)
memory. Since its discovery 30 years ago, mnemonic activity has been hypothesized to be …

Higher-order executive tasks such as learning, working memory, and behavioral flexibility
depend on the prefrontal cortex (PFC), the brain region most elaborated in primates. The …

During working memory tasks, the firing rates of single neurons recorded in behaving
monkeys remain elevated without external cues. Modeling studies have explored different …

Working memory represents the ability of the brain to hold externally or internally driven
information for relatively short periods of time,. Persistent neuronal activity is the elementary …

Mnemonic persistent activity in the prefrontal cortex (PFC) constitutes the neural basis of
working memory. To understand how neuromodulators contribute to the generation of …

In order to understand how the molecular or cellular defects that underlie a disease of the
nervous system lead to the observable symptoms, it is necessary to develop a large‐scale …