Sex bias in lymphocytes: Implications for autoimmune diseases

KC Dodd, M Menon - Frontiers in Immunology, 2022 - frontiersin.org
Autoimmune diseases are characterized by a significant sex dimorphism, with women
showing increased susceptibility to disease. This is, at least in part, due to sex-dependent …

Sex difference in human diseases: mechanistic insights and clinical implications

Y Shi, J Ma, S Li, C Liu, Y Liu, J Chen, N Liu… - … and Targeted Therapy, 2024 - nature.com
Sex characteristics exhibit significant disparities in various human diseases, including
prevalent cardiovascular diseases, cancers, metabolic disorders, autoimmune diseases …

What can we learn from sex differences in MS?

PK Coyle - Journal of personalized medicine, 2021 - mdpi.com
Multiple sclerosis (MS) is the major acquired central nervous system disease of young
adults. It is a female predominant disease. Multiple aspects of MS are influenced by sex …

Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice

N Itoh, Y Itoh, CE Meyer, TT Suen… - Nature …, 2023 - nature.com
Menopause is associated with cognitive deficits and brain atrophy, but the brain region and
cell-specific mechanisms are not fully understood. Here, we identify a sex hormone by age …

The right to sexuality, reproductive health, and found a family for people with intellectual disability: A systematic review

P Perez-Curiel, E Vicente, ML Moran… - International Journal of …, 2023 - mdpi.com
Although sexuality, reproductive health, and starting a family are human rights that should
be guaranteed for all citizens, they are still taboo issues for people with intellectual disability …

Potential biological contributers to the sex difference in multiple sclerosis progression

N Alvarez-Sanchez, SE Dunn - Frontiers in Immunology, 2023 - frontiersin.org
Multiple sclerosis (MS) is an immune-mediated disease that targets the myelin sheath of
central nervous system (CNS) neurons leading to axon injury, neuronal death, and …

Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis

RR Voskuhl, A MacKenzie-Graham - Frontiers in Molecular …, 2022 - frontiersin.org
Animal models of multiple sclerosis (MS), specifically experimental autoimmune
encephalomyelitis (EAE), have been used extensively to develop anti-inflammatory …

Quantitative effect of sex on disease activity and disability accumulation in multiple sclerosis

M Magyari, N Koch-Henriksen - Journal of Neurology, Neurosurgery …, 2022 - jnnp.bmj.com
Objective To quantify sex differences in activity and severity of multiple sclerosis (MS) and
how it depends on disease duration and time since clinical onset. Methods All Danish …

Sexual dimorphism in extracellular matrix composition and viscoelasticity of the healthy and inflamed mouse brain

CS Batzdorf, AS Morr, G Bertalan, I Sack, RV Silva… - Biology, 2022 - mdpi.com
Simple Summary In multiple sclerosis (MS), an autoimmune disease of the central nervous
system that primarily affects women, gender differences in disease course and in brain …

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

LE Salminen, MA Tubi, J Bright… - Human Brain …, 2022 - Wiley Online Library
Sex is a biological variable that contributes to individual variability in brain structure and
behavior. Neuroimaging studies of population‐based samples have identified normative …