Background Vancomycin is commonly used to treat gram-positive bacterial infections in the
paediatric population, but dosing can be challenging. Population pharmacokinetic (popPK) …

Background Moxifloxacin (MOX) is used as a first-choice drug to treat multidrug-resistant
tuberculosis (MDR-TB); however, evidence-based dosing optimization should be …

Objective: The aim of this study was to establish a population pharmacokinetic (PPK) model
of valproic acid (VPA) in pediatric patients with epilepsy in southern China, and provide …

Aim Several studies have reported population pharmacokinetic models for phenobarbital
(PB), but the predictive performance of these models has not been well documented. This …

Area under the curve (AUC)-directed vancomycin therapy is recommended, but Bayesian
AUC estimation in critically ill children is difficult due to inadequate methods for estimating …

Background: Vancomycin therapeutic monitoring guidelines were revised in March 2020,
and a population pharmacokinetics-guided Bayesian approach to estimate the 24-hour area …

Background: Adverse drug reactions are a problem in healthcare systems worldwide.
Children are more susceptible than adults, especially when exposed to specific drug …

Tacrolimus (FK506) is a cornerstone of GVHD-prophylaxis treatment in paediatrics
undergoing haematopoietic stem cell transplantation (HSCT). However, due to concerns …

Aims Our objectives were to perform a population pharmacokinetic analysis of
dexmedetomidine in children using remnant specimens and electronic health records …

Background: Adverse drug reactions are an important cause of morbidity and mortality in all
patients. Information regarding adverse drug reactions in the pediatric age group, especially …