GpsB links peptidoglycan synthases to other proteins that determine the shape of the
respiratory pathogen Streptococcus pneumoniae (pneumococcus; Spn) and other low‐GC …

For bacteria to increase in size, they need to enzymatically expand their cell envelopes, and
more concretely their peptidoglycan cell wall. A major task of growth is to increase …

The bacterial PASTA kinase, IreK, is required for intrinsic cephalosporin resistance in the
Gram‐positive opportunistic pathogen, Enterococcus faecalis. IreK activity is enhanced in …

For decades, cells of the Gram-positive bacterial pathogen Staphylococcus aureus were
thought to lack a dedicated elongation machinery. However, S. aureus cells were recently …

The trade-off between rapid growth and other important physiological traits (eg, survival and
adaptability) poses a fundamental challenge for microbes to achieve fitness maximization …

Most rod-shaped bacteria elongate by inserting new cell wall material into the inner surface
of the cell sidewall. This is performed by class A penicillin binding proteins (PBPs) and a …

Bacteria adapt the biosynthesis of their envelopes to specific growth conditions and
prevailing stress factors. Peptidoglycan (PG) is the major component of the cell wall in Gram …

Peptidoglycan (PG) and most surface glycopolymers and their modifications are built in the
cytoplasm on the lipid carrier undecaprenyl phosphate (UndP). These lipid-linked …

Accurate coordination of chromosome replication and cell division is essential for cellular
processes, yet the regulatory mechanisms governing the bacterial cell cycle remain …

Abstract StkP, the Ser/Thr protein kinase of the major human pathogen Streptococcus
pneumoniae, monitors cell wall signals and regulates growth and division in response. In …