Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals'
targeted and effective administration. However, the intricate interplay between drug …

Targeted protein degraders such as PROTACs and molecular glues are a rapidly emerging
therapeutic modality within industry and academia. Degraders possess unique mechanisms …

Abstract Machine learning (ML) systems can model quantitative structure-property
relationships (QSPR) using existing experimental data and make property predictions for …

Targeted protein degradation (TPD) is emerging as a promising therapeutic approach for
cancer and other diseases, with an increasing number of programs demonstrating its …

Molecular docking is a computational method based on bioinformatics that simulates the
interaction dynamics of molecules such as ligands and receptors, predicting their binding …

Targeted protein degradation (TPD) has greatly advanced as a therapeutic strategy in the
past two decades, and we are on the cusp of rationally designed protein degraders reaching …

Proteolysis-targeting chimeras (PROTACs) are drugs designed to degrade target proteins
via the ubiquitin-proteasome system. With the application of computational biology/chemistry …

Epigenetics refers to the reversible process through which changes in gene expression
occur without changing the nucleotide sequence of DNA. The process is currently gaining …

Undruggable targets typically refer to a class of therapeutic targets that are difficult to target
through conventional methods or have not yet been targeted, but are of great clinical …

PROTACs are a promising therapeutic modality that harnesses the cell's built-in degradation
machinery to degrade specific proteins. Despite their potential, developing new PROTACs is …