In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

The number of molecularly stratified treatment options available to patients with colorectal
cancer (CRC) is increasing, with a parallel rise in the use of biomarkers to guide …

CD68 is a heavily glycosylated glycoprotein that is highly expressed in macrophages and
other mononuclear phagocytes. Traditionally, CD68 is exploited as a valuable cytochemical …

Abstract CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast
cancer. However, their expression is not always consistent even in the same subtype of …

Recent clinical trials have demonstrated the ability to durably control cancer in some
patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer …

Epithelial to mesenchymal transition (EMT) is a process during which cells lose their
epithelial characteristics, for instance cell polarity and cell–cell contact, and gain …

Metastatic spread of tumour cells is the main cause of cancer-related deaths. Understanding
the mechanisms of tumour-cell dissemination has, therefore, become an important focus for …

The conversion of cells with an epithelial phenotype into cells with a mesenchymal
phenotype, referred to as epithelial–mesenchymal transition, is a critical process for …

Purpose: The ubiquitously expressed transmembrane glycoprotein CD47 delivers an anti-
phagocytic (do not eat) signal by binding signal-regulatory protein α (SIRPα) on …

Cancer metastasis is the main cause of cancer‐related death, and dissemination of tumor
cells through the blood circulation is an important intermediate step that also exemplifies the …