Current and emerging avenues for Alzheimer's disease drug targets

R Loera‐Valencia, A Cedazo‐Minguez… - Journal of internal …, 2019 - Wiley Online Library
Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …

[HTML][HTML] A comprehensive overview of the complex role of oxidative stress in aging, the contributing environmental stressors and emerging antioxidant therapeutic …

E Iakovou, M Kourti - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Introduction: Aging is a normal, inevitable, irreversible and progressive process which is
driven by internal and external factors. Oxidative stress, that is the imbalance between …

[HTML][HTML] The effect of nutrition on aging—A systematic review focusing on aging-related biomarkers

C Leitão, A Mignano, M Estrela, M Fardilha, A Figueiras… - Nutrients, 2022 - mdpi.com
Despite the increasing life expectancy, an individual's later years tends to be accompanied
by a decrease in the quality of life. Though biological changes that occur through the natural …

The environment as a determinant of successful aging or frailty

A Di Ciaula, P Portincasa - Mechanisms of ageing and development, 2020 - Elsevier
The number of elderly persons is rising rapidly, and healthspan is a key factor in determining
the well-being of individuals and the sustainability of national health systems. Environmental …

Factors associated with multimorbidity patterns in older adults in England: findings from the English Longitudinal Study of Aging (ELSA)

H Nguyen, KC Chua, A Dregan… - Journal of aging …, 2020 - journals.sagepub.com
Objective: We aimed to identify the patterns of multimorbidity in older adults and explored
their association with sociodemographic and lifestyle risk factors. Method: The sample …

[HTML][HTML] Association of Plant Protein Intake with change in physical performance in Chinese community-dwelling older adults

SSY Yeung, J Woo - Nutrients, 2022 - mdpi.com
(1) Background: Dietary protein intake might be beneficial in optimizing physical
performance, yet whether this is dependent on protein source and sex is unclear. We …

[HTML][HTML] Healthy ageing trajectories and lifestyle behaviour: the Mexican Health and Aging Study

C Daskalopoulou, A Koukounari, YT Wu, GM Terrera… - Scientific Reports, 2019 - nature.com
Projections show that the number of people above 60 years old will triple by 2050 in Mexico.
Nevertheless, ageing is characterised by great variability in the health status. In this study …

[HTML][HTML] A review of nutritional requirements of adults aged≥ 65 years in the UK

N Dorrington, R Fallaize, DA Hobbs, M Weech… - The Journal of …, 2020 - Elsevier
Appropriate dietary choices in later life may reduce the risk of chronic diseases and rate of
functional decline, however, there is little well-evidenced age-specific nutritional guidance in …

Association between combined lifestyle factors and healthy ageing in Chinese adults: the Singapore Chinese health study

YF Zhou, XY Song, XF Pan, L Feng… - The Journals of …, 2021 - academic.oup.com
Background The aim of the study was to examine the relations of individual lifestyle factors
and its composite score with healthy ageing among Chinese adults. Method We included 14 …

Alcohol use in older adults: A systematic review of biopsychosocial factors, screening tools, and treatment options

O Megherbi-Moulay, V Igier, B Julian… - International Journal of …, 2022 - Springer
Alcohol use among older adults, often denied, is a real public health problem in view of the
harmful consequences it induces. The objective of this systematic review was to identify …