Unprogrammed macrophage polarization, especially prolonged activation of
proinflammatory macrophages, is associated with delayed wound healing in diabetic …

NLRP3 plays a role in the development of autoinflammatory diseases. NLRP3, ASC, and
Caspases 1 or 8 make up the NLRP3 inflammasome, which is an important part of innate …

Garcimultiflins A–C (1–3), three novel polycyclic polyprenylated acylphloroglucinols
(PPAPs), were isolated from the pericarps of Garcinia multiflora. Their structures and …

Twelve undescribed limonoids, meliazedarines J–U (1–12), along with a known one, were
isolated from the roots of Melia azedarach. Their structures were elucidated by extensive …

N-acylethanolamines (NAEs) are endogenous lipid-signalling molecules involved in
inflammation and energy metabolism. The potential pharmacological effect of NAE …

Accumulating evidence strongly support the key role of NLRP3-mediated pyroptosis in the
pathogenesis and progression of vascular endothelial dysfunction associated with diabetes …

Objective Adipose tissue remodeling is a dynamic process that is pathologically expedited in
the obese state and is closely related to obesity-associated disease progression. This study …

Diet-induced obesity can cause metabolic syndromes. The critical link in disease
progression is adipose tissue macrophage (ATM) recruitment, which drives low-level …

Objectives: To investigate the prevalence of rs2015 (T> G) and rs2241703 (G> A)
polymorphisms in the miRNA-SIRT2 gene in Saudi Arabia and their possible associations …

Liver fibrosis is a crucial step in the progression of various chronic liver diseases to cirrhosis,
which can affect the prognosis of chronic liver diseases. The NAD+ dependent deacetylase …