Patients with cancer carry somatic sequence variants in their tumour in addition to the
germline variants in their inherited genome. Although variants in protein-coding regions …

Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53,
playing a key role in controlling its transcriptional activity, protein stability, and nuclear …

Abstract p53 is a powerful tumor suppressor and is an attractive cancer therapeutic target
because it can be functionally activated to eradicate tumors. The gene encoding p53 protein …

p53 mutations are found in 50% of human cancers. Molecular epidemiology has shown
strong correlations between the spectrum of p53 mutations and exposure to exogenous …

Abstract AG> C polymorphism (rs2910164) is located in the stem region opposite to the
mature miR-146a sequence, which results in a change from G: U pair to C: U mismatch in …

The formation of micronuclei (MN) is extensively used in molecular epidemiology as a
biomarker of chromosomal damage, genome instability, and eventually of cancer risk. The …

The p53 pathway is perturbed in the majority of human cancers. Although this most
frequently occurs through the direct mutation or deletion of p53 itself, there are a number of …

Abstract Background Many Single Nucleotide Polymorphism (SNP) calling programs have
been developed to identify Single Nucleotide Variations (SNVs) in next-generation …

Sex is a key biological factor affecting the development of many cancer types. There are
considerable differences between male and female subpopulations in terms of cancer …