Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …

Cooling can reduce primary injury and prevent secondary injury to the brain after insults in
certain clinical settings and in animal models of brain insult. The mechanisms that underlie …

The susceptibility of the brain to ischaemic injury dramatically limits its viability following
interruptions in blood flow. However, data from studies of dissociated cells, tissue …

In the United States stroke is the third leading cause of death and the leading cause of
disability. Brain injury following stroke results from the complex interplay of multiple …

Cerebral ischemic preconditioning protects against stroke, but is clinically feasible only
when the occurrence of stroke is predictable. Reperfusion plays a critical role in cerebral …

The ischemic penumbra is both a concept in understanding the evolution of cerebral tissue
injury outcome of focal ischemia and a potential therapeutic target for ischemic stroke. In this …

Therapeutic hypothermia, or cooling of the body or brain for the purposes of preserving
organ viability, is one of the most robust neuroprotectants at both the preclinical and clinical …

We have previously shown that in neonatal rats subjected to hypoxia-ischemia (HI)
rapamycin administration increases autophagy, decreases apoptosis and significantly …

Cerebral ischemia/reperfusion (I/R) injury often leads to irreversible neuronal injury and
even death, and hypothermia is the only therapeutic method that has been proven to be …