Metagenomic samples are snapshots of complex ecosystems at work. They comprise
hundreds of known and unknown species, contain multiple strain variants and vary greatly …

Decoding DNA symbols using next-generation sequencers was a major breakthrough in
genomic research. Despite the many advantages of next-generation sequencers, eg, the …

Background The recent introduction of the Pacific Biosciences RS single molecule
sequencing technology has opened new doors to scaffolding genome assemblies in a cost …

Motivation: Completing the genome sequence of an organism is an important task in
comparative, functional and structural genomics. However, this remains a challenging issue …

Previous studies have reported that chromosome synteny in Lepidoptera has been well
conserved, yet the number of haploid chromosomes varies widely from 5 to 223. Here we …

Background Genome assembly is typically a two-stage process: contig assembly followed
by the use of paired sequencing reads to join contigs into scaffolds. Scaffolds are usually the …

Background Recent advances in genomics indicate functional significance of a majority of
genome sequences and their long range interactions. As a detailed examination of genome …

The current genomic revolution was made possible by joint advances in genome
sequencing technologies and computational approaches for analyzing sequence data. The …

Background The use of short reads from High Throughput Sequencing (HTS) techniques is
now commonplace in de novo assembly. Yet, obtaining contiguous assemblies from short …

The next-generation sequencing (NGS) revolution has drastically reduced time and cost
requirements for sequencing of large genomes, and also qualitatively changed the problem …