Thiazole: A promising heterocycle for the development of potent CNS active agents

CB Mishra, S Kumari, M Tiwari - European journal of medicinal chemistry, 2015 - Elsevier
Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to
display a variety of biological activities. Thiazole and its derivatives have attracted …

Adenosine receptor antagonists: Recent advances and therapeutic perspective

A Saini, R Patel, S Gaba, G Singh, GD Gupta… - European Journal of …, 2022 - Elsevier
Adenosine is an endogenous purine-based nucleoside expressed nearly in all body tissues.
It regulates various body functions by activating four G-protein coupled receptors, A 1, A 2A …

Role of rutin nanoemulsion in ameliorating oxidative stress: pharmacokinetic and pharmacodynamics studies

S Sharma, SA Rabbani, JK Narang, FH Pottoo… - Chemistry and physics …, 2020 - Elsevier
Parkinson's disease is caused due to free radical generation in dopamine neurons leading
to oxidative stress induced damage. The aim of this work was to ameliorate the free radical …

History and Perspectives of A2A Adenosine Receptor Antagonists as Potential Therapeutic Agents

D Preti, PG Baraldi, AR Moorman… - Medicinal research …, 2015 - Wiley Online Library
Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as
a local regulator in different pathologies. Adenosine is a ubiquitous nucleoside involved in …

Haloperidol‐induced catalepsy as an animal model for parkinsonism: A systematic review of experimental studies

I Waku, MS Magalhaes, CO Alves… - European Journal of …, 2021 - Wiley Online Library
Several useful animal models for parkinsonism have been developed so far. Haloperidol‐
induced catalepsy is often used as a rodent model for the study of motor impairments …

Copper-Catalyzed Coupling Cyclization of gem-Difluoroalkenes with Activated Methylene Carbonyl Compounds: Facile Domino Access to Polysubstituted Furans

X Zhang, W Dai, W Wu, S Cao - Organic letters, 2015 - ACS Publications
A novel and efficient CuI-catalyzed synthesis of 2, 3, 5-trisubstituted furans was developed
via coupling cyclization of gem-difluoroalkenes with active methylene carbonyl compounds …

Synthesis of Tetrasubstituted Furans through One-Pot Formal [3+ 2] Cycloaddition Utilizing [1, 2]-Phospha-Brook Rearrangement

A Kondoh, K Aita, S Ishikawa, M Terada - Organic letters, 2020 - ACS Publications
An efficient method for the synthesis of tetrasubstituted furans was developed by utilizing the
[1, 2]-phospha-Brook rearrangement under Brønsted base catalysis. The two-step one-pot …

[3+ 2] Cycloaddition of α-Aryl-α-diazoacetates with Terminal Alkynes via the Cooperative Catalysis of Palladium and Acid

H Guo, S Zhang, X Yu, X Feng, Y Yamamoto… - ACS Catalysis, 2021 - ACS Publications
Palladium and acid cooperative catalysis is presented as a strategy for the [3+ 2]
cycloaddition of acceptor/donor-type diazo compounds with terminal alkynes. The [3+ 2] …

FeCl 3 or MeSO 3 H-promoted multicomponent reactions for facile synthesis of structurally diverse furan analogues

X Chang, X Zhang, Z Chen - Organic & biomolecular chemistry, 2018 - pubs.rsc.org
An intriguing conversion of arylglyoxal, cyclic dicarbonyl compounds and phenols to diverse
furan analogues under FeCl3 or MeSO3H catalysis is reported. Utilizing this synthetic …

Solvent-Free DABCO-mediated [3+ 2] cycloadditions of donor–acceptor cyclopropanes with aldehydes: strategy for synthesis of fully substituted furans

J Liu, W Ye, X Qing, C Wang - The Journal of Organic Chemistry, 2016 - ACS Publications
DABCO-mediated [3+ 2] cycloadditions of donor–acceptor cyclopropanes with aldehydes
under solvent-free conditions have been developed for the preparation of fully substituted …