Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

The endocannabinoid system (ECS) is an important brain modulatory network. ECS
regulates brain homeostasis throughout development, from progenitor fate decision to neuro …

Cholesterol is a fundamental lipid prevalent in eukaryotic cell membranes and circulating in
the bloodstream bound to lipoproteins. It serves as a precursor to steroid hormones and is …

The decriminalization and legalization of cannabis has paved the way for investigations into
the potential of the use of phytocannabinoids (pCBs) as natural therapeutics for the …

Cholesterol is an important component of plasma membranes and participates in many
basic life functions, such as the maintenance of cell membrane stability, the synthesis of …

Abstract Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol
transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to …

The loss of NPC1 or NPC2 function results in cholesterol and sphingolipid dyshomeostasis
that impairs developmental trajectories, predisposing the postnatal brain to the appearance …

Adequate homeostasis of lipid, protein and carbohydrate metabolism is essential for cells to
perform highly specific tasks in our organism, and the brain, with its uniquely high energetic …

Acid sphingomyelinase deficiency (ASMD) leads to cellular accumulation of sphingomyelin
(SM), neurodegeneration, and early death. Here, we describe the downregulation of the …

Cholesterol is the most considerable member of a family of polycyclic compounds
understood as sterols, and represents an amphipathic molecule, such as phospholipids …